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A differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by glatiramer acetate in relapsing-remitting multiple sclerosis patients

dc.creatorAvila, Sandraes_ES
dc.creatorGuerrero-García, José de Jesúses_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorPavón, Lenines_ES
dc.creatorRojas-Mayorquín, Argelia E.es_ES
dc.creatorMireles-Ramírez, Mario Albertoes_ES
dc.creatorMuñoz-Valle, José Franciscoes_ES
dc.creatorVallejo-Castillo, Luises_ES
dc.creatorMedina-Rivero, Emilioes_ES
dc.creatorOrtuño-Sahagún, Danieles_ES
dc.creatorPérez-Tapia, Sonia Mayraes_ES
dc.date2019
dc.date.accessioned2022-11-17T18:43:07Z
dc.date.available2022-11-17T18:43:07Z
dc.date.issued2019
dc.identifierJC12NC22es_ES
dc.identifier.issn2211-0348
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7626
dc.identifier.urihttps://doi.org/10.1016/j.msard.2019.06.021
dc.descriptionBackground: Glatiramer acetate (GA) is a drug for Multiple Sclerosis (MS) treatment. However, its administration induces anti-drug antibodies (ADA). This research evaluated the sex differences in humoral response against GA in RR-MS patients METHODS: We analyzed 69 RR-MS patients, 43 treated with GA and 26 treated with IFN-β. In all cases, the serum concentration of IgG antibodies was determined by UPLC, whereas the levels of IgG subclasses (1-4) of anti-GA antibodies and the concentration of IL-6 were detected by Multiplex and IL-10, and IFN-γ were detected by ELISA. Results: The total concentration of IgG antibodies in patients did not differ between treatments, whereas the IgG levels of ADA were higher in male and female patients treated with GA (P ≤ 0.0001). The subclasses of IgG anti-GA antibodies were as follows: IgG4>>IgG3>IgG1>IgG2. Statistical analysis showed differences in the IgG2 (P ≤ 0.01) and IgG4 (P ≤ 0.0001) subclasses by sex in RR-MS patients. Levels of IgG1 subclass in male patients correlated positively with the circulatory levels of IL-6 (rs = 0.587, P ≤ 0.04) and IFN-γ (rs = 0.721, P ≤ 0.001), while IgG2 subclass levels in female patients correlated with serum levels of IFN-γ (rs = 0.628, P ≤ 0.0006). Statistical analysis did not detect correlations between the levels of IgG (1-4) subclasses of anti-GA antibodies and the evaluated clinical parameters. Conclusion: This study showed differences in the levels of IgG2 and IgG4 subclasses of ADA between male and female RR-MS patients. Further studies are necessary to take advantage of the clinical potential of this finding.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier B. V.es_ES
dc.relation34:92-99
dc.rightsAcceso Cerradoes_ES
dc.titleA differential sex-specific pattern of IgG2 and IgG4 subclasses of anti-drug antibodies (ADAs) induced by glatiramer acetate in relapsing-remitting multiple sclerosis patientses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Instituto Politécnico Nacional, Mexico City, México
dc.contributor.emailsndrxavila@comunidad.unam.mx (S. Avila), guerrero.garcia@sems.udg.mx (J.d.J. Guerrero-García), lusenbeve@imp.edu.mx (E. Becerril-Villanueva), gilberto.perez.sanchez@imp.edu.mx (G. Pérez-Sánchez), lkuriaki@imp.edu.mx (L. Pavón), argelia.rojas@academicos.udg.mx (A.E. Rojas-Mayorquín), mario.mirelesr@imss.gob.mx (M.A. Mireles-Ramírez), drjosefranciscomv@cucs.udg.mx (J.F. Muñoz-Valle), lavallejos@ipn.mx (L. Vallejo-Castillo), medina@udibi.com.mx (E. Medina-Rivero), dortuno@cucs.udg.mx (D. Ortuño-Sahagún), cipft.encb@gmail.com (S.M. Pérez-Tapia).
dc.relation.jnabreviadoMULT SCLER RELAT DISORD
dc.relation.journalMultiple Sclerosis and Related Disorders
dc.identifier.placePaíses Bajos
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2211-0356
dc.identifier.doi10.1016/j.msard.2019.06.021
dc.subject.kwIgG2
dc.subject.kwIgG4
dc.subject.kwGlatiramer acetate
dc.subject.kwMale and female differences
dc.subject.kwADA


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