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Magnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature rats

dc.creatorVega-García, A.es_ES
dc.creatorSantana-Gómez, C. E.es_ES
dc.creatorRocha, L.es_ES
dc.creatorMagdaleno-Madrigal, V. M.es_ES
dc.creatorMorales-Otal, A.es_ES
dc.creatorBuzoiano-Anguiano, V.es_ES
dc.creatorFeria-Romero, I.es_ES
dc.creatorOrozco-Suárez, S.es_ES
dc.date2019
dc.date.accessioned2022-11-17T17:20:16Z
dc.date.available2022-11-17T17:20:16Z
dc.date.issued2019
dc.identifierJC11NC22es_ES
dc.identifier.issn0361-9230
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7625
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2019.04.003
dc.descriptionDuring critical periods of neurodevelopment, the immature brain is susceptible to neuronal hyperexcitability, alterations such as hyperthermia, hypoxia, brain trauma or a preexisting neuroinflammatory condition can trigger, promote and prolong epileptiform activity and facilitate the development of epilepsy. The goal of the present study was to evaluate the long-term neuroprotective effects Magnolia officinalis extract, on a model of recurrent status epilepticus (SE) in immature rats. Sprague-Dawley rats were treated with kainic acid (KA) (3 mg/kg, dissolved in saline solution) beginning at day 10 P N every 24 h for five days (10 P N-14PN). Two experimental groups (KA) received two treatments for 10 days (14-24 P N): one group was treated with 300 mg/kg Magnolia Officinalis (MO) (KA-MO), and another was treated with 20 mg/kg of celecoxib (Clbx) (KA-Clbx) as a control drug. A SHAM control group at day 90 P N was established. Seizure susceptibility was analyzed through an after-discharge threshold (ADT) evaluation, and electroencephalographic activity was recorded. The results obtained from the ADT evaluation and the analysis of the electroencephalographic activity under basal conditions showed that the MO and Clbx treatments protected against epileptiform activity, and decreases long-term excitability. All rats in the KA-MO and KA-Clbx groups presented a phase I seizure on the Racine scale, corresponding to the shaking of a wet dog. In contrast, the KA group showed phase V convulsive activity on the Racine scale. Similarly, MO and Clbx exerted neuroprotective effects on hippocampal neurons and reduced gliosis in the same areas. Based on these results, early intervention with MO and Clbx treatments to prevent the inflammatory activity derived from SE in early phases of neurodevelopment exerts neuroprotective effects on epileptogenesis in adult stages.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier Sciencees_ES
dc.relation149:156-167
dc.rightsAcceso Cerradoes_ES
dc.titleMagnolia officinalis reduces the long-term effects of the status epilepticus induced by kainic acid in immature ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationPrograma de Doctorado del Departamento de Ciencias Biológicas y de la Salud, UAM-I, Universidad Autónoma Metropolitana Campus Iztapalapa, Ciudad de México, Mexico
dc.contributor.emailsorozco5@hotmail.com, sandra.orozcos@imss.gob.mx (S. Orozco-Suárez).
dc.relation.jnabreviadoBRAIN RES BULL
dc.relation.journalBrain Research Bulletin
dc.identifier.placeEstados Unidos
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1873-2747
dc.identifier.doi10.1016/j.brainresbull.2019.04.003
dc.subject.kwMagnolia officinalis
dc.subject.kwHonokiol
dc.subject.kwMagnolol
dc.subject.kwEarly seizures
dc.subject.kwNeuroprotection
dc.subject.kwKainic acid
dc.subject.kwEpileptogenesis


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