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D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat

dc.creatorMercado-Reyes, Jonathanes_ES
dc.creatorAlmanza, Angélicaes_ES
dc.creatorSegura-Chama, Pedroes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorMercado, Franciscoes_ES
dc.date2019
dc.date.accessioned2022-11-09T15:57:56Z
dc.date.available2022-11-09T15:57:56Z
dc.date.issued2019
dc.identifierJC08NC22es_ES
dc.identifier.issn0014-2999
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7619
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2019.03.020
dc.descriptionOpioids are potent analgesic drugs, but their use has been limited due to their side effects. Antinociceptive effects of D2-like receptor agonists such as quinpirole have been shown at the spinal cord level; however, their efficacy is not as high as that of opioids. Dopaminergic agonists are long-prescribed and well-tolerated drugs that have been useful to treat clinically and experimentally painful conditions. Because current pain treatments are not completely effective, the aim of this work was to determine if a D2-like receptor agonist improves the antinociceptive effects of a μ-opioid receptor agonist. Drugs were intrathecally administered in adult rats; mechanonociceptive and thermonociceptive tests were carried out. Intraplantar injection of complete Freund's adjuvant (CFA) and sciatic loose ligation (SLL) were used for inflammatory and neuropathic models of pain, respectively. In intact animals, D-Ala2, N-MePhe4, Gly-ol-enkephalin (DAMGO; a µ-opioid receptor agonist) increased the paw withdrawal latencies (PWL) in thermal and mechanical nociceptive tests in a dose-dependent manner. Quinpirole (D2-like receptor agonist) increased PWL only in mechanonociception. In the presence of quinpirole (1 nmol), the ED50 of the mechanical antinociceptive effect of DAMGO was significantly decreased (8-fold). Coadministration of 1 nmol quinpirole and 30 pmol DAMGO completely reversed hyperalgesia in the CFA model, whereas 100 pmol DAMGO plus 1 nmol quinpirole reversed the allodynia in the SLL model. This work offers evidence about a synergistic antinociceptive effect between opioidergic and dopaminergic drugs. This combination may relieve painful conditions resistant to conventional treatments, and it may reduce the adverse effects of chronic opioid administration.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier Sciencees_ES
dc.relation853:56-64
dc.rightsAcceso Cerradoes_ES
dc.titleD2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rates_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Fisiología Celular, Dirección de Investigaciones en Neurociencias. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emailfmercado@imp.edu.mx, mercado.aca@gmail.com (F. Mercado)
dc.relation.jnabreviadoEUR J PHARMACOL
dc.relation.journalEuropean Journal of Pharmacology
dc.identifier.placePaíses Bajos
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1879-0712
dc.identifier.doi10.1016/j.ejphar.2019.03.020
dc.subject.kwDopamine
dc.subject.kwModulation
dc.subject.kwOpioid receptors
dc.subject.kwD2-like receptors
dc.subject.kwAnalgesia
dc.subject.kwNeuropathic pain


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