Mostrar el registro sencillo del ítem

Neurobehavioral and toxicological effects of an aqueous extract of Turnera diffusa Willd (Turneraceae) in mice

dc.creatorDorantes-Barrón, Ana Maríaes_ES
dc.creatorVigueras Villaseñor, Rosa Maríaes_ES
dc.creatorMayagoitia-Novales, Lilianes_ES
dc.creatorMartínez-Mota, Lucíaes_ES
dc.creatorGutiérrez-Pérez, Oscares_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.date2019
dc.date.accessioned2022-11-08T16:29:17Z
dc.date.available2022-11-08T16:29:17Z
dc.date.issued2019
dc.identifierJC07NC22es_ES
dc.identifier.issn0378-8741
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7618
dc.identifier.urihttp://doi.org/10.1016/j.jep.2019.02.036
dc.descriptionAims: To explore the antidepressant- and anxiolytic-like effects of an aqueous extract of Turnera diffusa Willd (Turneraceae) and to explore its possible toxic side effects on behavior, target organ function, and spermatic quality. Materials and methods: Acute effects of a T. diffusa aqueous extract were evaluated in adult male mice with the plus-maze, forced swimming and open field tests to identify the possible anxiolytic, antidepressant and stimulant effects of this extract. Effects of T. diffusa aqueous extract were further investigated through two approaches. a) Male and female adult mice receiving a 28-day treatment were evaluated in a neurobehavioral test battery; later, changes in their biochemical parameters and in target organ morphology were analyzed. b) In young adult (16-weeks old) and mature (46-weeks old) males, spermatic quality and testes morphology during a complete spermatogenesis cycle were analyzed after a 35-day treatment. Results: T. diffusa aqueous extract induced remarkable anxiolytic- and antidepressant-like effects without affecting locomotor activity. This extract did not elicit behavioral signs of neural side effects, a sex-dependent reduction in body weight gain was produced without affecting functional parameters or the morphology of target organs. The highest dose improved cellular turnover in the testes of mature mice. Conclusion: T. diffusa aqueous extract induced a clear anxiolytic-like effect, and for the first time, we reported an antidepressant effect. Clinical potential or even intake of T. diffusa in the context of traditional medicine can be supported by its efficacy to positively modulate behavior and its safety for a wide range of doses.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevier Sequoiaes_ES
dc.relation236:50-62
dc.rightsAcceso Cerradoes_ES
dc.titleNeurobehavioral and toxicological effects of an aqueous extract of Turnera diffusa Willd (Turneraceae) in micees_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370 CDMX, Mexico
dc.contributor.emailrestrada@imp.edu.mx (Estrada-Reyes. Rosa)
dc.relation.jnabreviadoJ ETHNOPHARMACOL
dc.relation.journalJournal of Ethnopharmacology
dc.identifier.placeIrlanda
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-7573
dc.identifier.doi10.1016/j.jep.2019.02.036
dc.subject.kwT. diffusa
dc.subject.kwAntidepressant
dc.subject.kwAnxiolytic
dc.subject.kwAdaptogenic
dc.subject.kwTesticular function spermatic integrity
dc.subject.kwDiazepam (PubChem CID: 3016)
dc.subject.kwFluoxetine (PubChem CID: 62857)


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem