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CD80 Expression Correlates with IL-6 Production in THP-1-Like Macrophages Costimulated with LPS and Dialyzable Leukocyte Extract (Transferon®)

dc.creatorJiménez-Uribe, Alexis P.es_ES
dc.creatorValencia-Martínez, Hugoes_ES
dc.creatorCarballo-Uicab, Gregorioes_ES
dc.creatorVallejo-Castillo, Luises_ES
dc.creatorMedina-Rivero, Emilioes_ES
dc.creatorChacón-Salinas, Rommeles_ES
dc.creatorPavón, Lenines_ES
dc.creatorVelasco-Velázquez, Marco A.es_ES
dc.creatorMellado-Sánchez, Gabrielaes_ES
dc.creatorEstrada-Parra, Sergioes_ES
dc.creatorPérez-Tapia, Sonia M.es_ES
dc.date2019
dc.date.accessioned2022-11-07T18:04:54Z
dc.date.available2022-11-07T18:04:54Z
dc.date.issued2019
dc.identifierJC06NC22es_ES
dc.identifier.issn2314-8861
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7617
dc.identifier.urihttps://doi.org/10.1155/2019/2198508
dc.descriptionTransferon® is a complex drug based on a mixture of low molecular weight peptides. This biotherapeutic is employed as a coadjuvant in clinical trials of several diseases, including viral infections and allergies. Given that macrophages play key roles in pathogen recognition, phagocytosis, processing, and antigen presentation, we evaluated the effect of Transferon® on phenotype and function of macrophage-like cells derived from THP-1 monocytes. We determined the surface expression of CD80 and CD86 by flow cytometry and IL-1β, TNF-α, and IL-6 levels by ELISA. Transferon® alone did not alter the steady state of PMA-differentiated macrophage-like THP-1 cells. On the contrary, simultaneous stimulation of cells with Transferon® and LPS elicited a significant increase in CD80 (P ≤ 0.001) and CD86 (P ≤ 0.001) expression, as well as in IL-6 production (P ≤ 0.05) compared to the LPS control. CD80 expression and IL-6 production exhibited a positive correlation (r = 0.6, P ≤ 0.05) in cells exposed to Transferon® and LPS. Our results suggest that the administration of Transferon® induces the expression of costimulatory molecules and the secretion of cytokines in LPS-activated macrophages. Further studies are necessary to determine the implication of these findings in the therapeutic properties of Transferon®.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.relation2019:2198508
dc.rightsAcceso Cerradoes_ES
dc.titleCD80 Expression Correlates with IL-6 Production in THP-1-Like Macrophages Costimulated with LPS and Dialyzable Leukocyte Extract (Transferon®)es_ES
dc.typeArtículoes_ES
dc.contributor.affiliationUnidad de Desarrollo e Investigación en Bioprocesos (UDIBI), Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
dc.contributor.emaillkuriaki@imp.edu.mx (Lenin Pavón), cipft.encb@gmail.com (Sonia M . Pérez-Tapia)
dc.relation.jnabreviadoJ IMMUNOL RES
dc.relation.journalJournal of Immunology Research
dc.identifier.placeEgipto
dc.date.published2019
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn2314-7156
dc.identifier.doi10.1155/2019/2198508


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