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Childhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveys

dc.creatorVries, Ymkje Anna dees_ES
dc.creatorAl-Hamzawi, Alies_ES
dc.creatorAlonso, Jordies_ES
dc.creatorBorges, Guilhermees_ES
dc.creatorBruffaerts, Ronnyes_ES
dc.creatorBunting, Brendanes_ES
dc.creatorCaldas-de-Almeida, José Migueles_ES
dc.creatorCia, Alfredo H.es_ES
dc.creatorGirolamo, Giovanni Dees_ES
dc.creatorDinolova, Rumyana V.es_ES
dc.creatorEsan, Oluyomies_ES
dc.creatorFlorescu, Silviaes_ES
dc.creatorGureje, Oyees_ES
dc.creatorHaro, Josep Mariaes_ES
dc.creatorHu, Chiyies_ES
dc.creatorKaram, Elie G.es_ES
dc.creatorKaram, Aimeees_ES
dc.creatorKawakami, Noritoes_ES
dc.creatorKiejna, Andrzejes_ES
dc.creatorKovess-Masfety, Vivianees_ES
dc.creatorLee, Singes_ES
dc.creatorMneimneh, Zeinaes_ES
dc.creatorNavarro-Mateu, Fernandoes_ES
dc.creatorPiazza, Marinaes_ES
dc.creatorScott, Katees_ES
dc.creatorHave, Margreet tenes_ES
dc.creatorTorres, Yolandaes_ES
dc.creatorViana, Maria Carmenes_ES
dc.creatorKessler, Ronald C.es_ES
dc.creatorJonge, Peter dees_ES
dc.creatorWHO World Mental Health Survey Collaboratorses_ES
dc.creatorBenjet, Corinaes_ES
dc.creatorMedina-Mora, María Elenaes_ES
dc.date2019
dc.date.accessioned2022-07-12T19:01:49Z
dc.date.available2022-07-12T19:01:49Z
dc.date.issued2019
dc.identifierJC012es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7552
dc.identifier.urihttps://doi.org/10.1186/s12916-019-1328-3es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533738/es_ES
dc.descriptionBackground: Specific phobia (SP) is a relatively common disorder associated with high levels of psychiatric comorbidity. Because of its early onset, SP may be a useful early marker of internalizing psychopathology, especially if generalized to multiple situations. This study aimed to evaluate the association of childhood generalized SP with comorbid internalizing disorders. Methods: We conducted retrospective analyses of the cross-sectional population-based World Mental Health Surveys using the Composite International Diagnostic Interview. Outcomes were lifetime prevalence, age of onset, and persistence of internalizing disorders; past-month disability; lifetime suicidality; and 12-month serious mental illness. Logistic and linear regressions were used to assess the association of these outcomes with the number of subtypes of childhood-onset (< 13 yesar) SP. Results: Among 123,628 respondents from 25 countries, retrospectively reported prevalence of childhood SP was 5.9%, 56% of whom reported one, 25% two, 10% three, and 8% four or more subtypes. Lifetime prevalence of internalizing disorders increased from 18.2% among those without childhood SP to 46.3% among those with one and 75.6% those with 4+ subtypes (OR = 2.4, 95% CI 2.3–2.5, p < 0.001). Twelve-month persistence of lifetime internalizing comorbidity at interview increased from 47.9% among those without childhood SP to 59.0% and 79.1% among those with 1 and 4+ subtypes (OR = 1.4, 95% CI 1.4–1.5, p < 0.001). Respondents with 4+ subtypes also reported significantly more disability (3.5 days out of role in the past month) than those without childhood SP (1.1 days) or with only 1 subtype (1.8 days) (B = 0.56, SE 0.06, p < 0.001) and a much higher rate of lifetime suicide attempts (16.8%) than those without childhood SP (2.0%) or with only 1 subtype (6.5%) (OR = 1.7, 95% CI 1.7–1.8, p < 0.001). Conclusions: This large international study shows that childhood-onset generalized SP is related to adverse outcomes in the internalizing domain throughout the life course. Comorbidity, persistence, and severity of internalizing disorders all increased with the number of childhood SP subtypes. Although our study cannot establish whether SP is causally associated with these poor outcomes or whether other factors, such as a shared underlying vulnerability, explain the association, our findings clearly show that childhood generalized SP identifies an important target group for early intervention.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation17(101)1-11es_ES
dc.rightsAcceso Cerradoes_ES
dc.titleChildhood generalized specific phobia as an early marker of internalizing psychopathology across the lifespan: results from the World Mental Health Surveyses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationFaculty of Behavioural and Social Sciences, Department of Developmental Psychology, University of Groningen, Groningen, the Netherlandses_ES
dc.contributor.emaily.a.de.vries@rug.nles_ES
dc.relation.jnabreviadoBMC MEDes_ES
dc.relation.journalBMC medicinees_ES
dc.identifier.placeInglaterraes_ES
dc.date.published2019es_ES
dc.identifier.eissn1741-7015es_ES
dc.identifier.doi10.1186/s12916-019-1328-3.
dc.subject.kwSpecific phobiaes_ES
dc.subject.kwInternalizing disorderses_ES
dc.subject.kwEarly markerses_ES
dc.subject.kwComorbidityes_ES
dc.subject.kwSuicidalityes_ES


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