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Association of adverse outcomes with emotion processing and its neural substrate in individuals at clinical high risk for psychosis

dc.creatorModinos, Gemmaes_ES
dc.creatorKempton, Matthew J.es_ES
dc.creatorTognin, Stefaniaes_ES
dc.creatorCalem, Mariaes_ES
dc.creatorPorffy, Lillaes_ES
dc.creatorAntoniades, Mathildees_ES
dc.creatorMason, Avaes_ES
dc.creatorAzis, Matildaes_ES
dc.creatorAllen, Paules_ES
dc.creatorNelson, Barnabyes_ES
dc.creatorMcGorry, Patrickes_ES
dc.creatorPantelis, Christoses_ES
dc.creatorRiecher-Rössler, Anitaes_ES
dc.creatorBorgwardt, Stefanes_ES
dc.creatorBressan, Rodrigoes_ES
dc.creatorBarrantes-Vidal, Neuses_ES
dc.creatorKrebs, Marie-Odilees_ES
dc.creatorNordentoft, Meretees_ES
dc.creatorGlenthøj, Birtees_ES
dc.creatorRuhrmann, Stephanes_ES
dc.creatorSachs,Gabrielees_ES
dc.creatorRutten, Bartes_ES
dc.creatorOs, Jim vanes_ES
dc.creatorHaan, Lieuwe dees_ES
dc.creatorVelthorst, Evaes_ES
dc.creatorGaag, Mark van deres_ES
dc.creatorValmaggia, Lucia R.es_ES
dc.creatorMcGuire, Philipes_ES
dc.creatorEU-GEI High Risk Study Groupes_ES
dc.creatorDomínguez-Martínez, Tecellies_ES
dc.date2020es_ES
dc.date.accessioned2022-07-06T17:33:22Z
dc.date.available2022-07-06T17:33:22Z
dc.date.issued2020es_ES
dc.identifierJC009es_ES
dc.identifier.issn2168-622Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7545
dc.identifier.urihttp://doi.org/10.1001/jamapsychiatry.2019.3501es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6865249/es_ES
dc.descriptionImportance The development of adverse clinical outcomes in patients with psychosis has been associated with behavioral and neuroanatomical deficits related to emotion processing. However, the association between alterations in brain regions subserving emotion processing and clinical outcomes remains unclear. Objective To examine the association between alterations in emotion processing and regional gray matter volumes in individuals at clinical high risk (CHR) for psychosis, and the association with subsequent clinical outcomes. Design, Setting, and Participants This naturalistic case-control study with clinical follow-up at 12 months was conducted from July 1, 2010, to August 31, 2016, and collected data from 9 psychosis early detection centers (Amsterdam, Basel, Cologne, Copenhagen, London, Melbourne, Paris, The Hague, and Vienna). Participants (213 individuals at CHR and 52 healthy controls) were enrolled in the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) project. Data were analyzed from October 1, 2018, to April 24, 2019. Main Measures and Outcomes Emotion recognition was assessed with the Degraded Facial Affect Recognition Task. Three-Tesla magnetic resonance imaging scans were acquired from all participants, and gray matter volume was measured in regions of interest (medial prefrontal cortex, amygdala, hippocampus, and insula). Clinical outcomes at 12 months were evaluated for transition to psychosis using the Comprehensive Assessment of At-Risk Mental States criteria, and the level of overall functioning was measured through the Global Assessment of Functioning [GAF] scale. Results A total of 213 individuals at CHR (105 women [49.3%]; mean [SD] age, 22.9 [4.7] years) and 52 healthy controls (25 women [48.1%]; mean [SD] age, 23.3 [4.0] years) were included in the study at baseline. At the follow-up within 2 years of baseline, 44 individuals at CHR (20.7%) had developed psychosis and 169 (79.3%) had not. Of the individuals at CHR reinterviewed with the GAF, 39 (30.0%) showed good overall functioning (GAF score, ≥65), whereas 91 (70.0%) had poor overall functioning (GAF score, <65). Within the CHR sample, better anger recognition at baseline was associated with worse functional outcome (odds ratio [OR], 0.88; 95% CI, 0.78-0.99; P = .03). In individuals at CHR with a good functional outcome, positive associations were found between anger recognition and hippocampal volume (ze = 3.91; familywise error [FWE] P = .02) and between fear recognition and medial prefrontal cortex volume (z = 3.60; FWE P = .02), compared with participants with a poor outcome. The onset of psychosis was not associated with baseline emotion recognition performance (neutral OR, 0.93; 95% CI, 0.79-1.09; P = .37; happy OR, 1.03; 95% CI, 0.84-1.25; P = .81; fear OR, 0.98; 95% CI, 0.85-1.13; P = .77; anger OR, 1.00; 95% CI, 0.89-1.12; P = .96). No difference was observed in the association between performance and regional gray matter volumes in individuals at CHR who developed or did not develop psychosis (FWE P < .05). Conclusions and Relevance In this study, poor functional outcome in individuals at CHR was found to be associated with baseline abnormalities in recognizing negative emotion. This finding has potential implications for the stratification of individuals at CHR and suggests that interventions that target socioemotional processing may improve functional outcomes.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAmerican Medical Associationes_ES
dc.relation77(2)190-200.es_ES
dc.relationversión del editores_ES
dc.rightsAcceso Cerradoes_ES
dc.titleAssociation of adverse outcomes with emotion processing and its neural substrate in individuals at clinical high risk for psychosises_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartment of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom.es_ES
dc.contributor.emailgemma.modinos@kcl.ac.ukes_ES
dc.relation.jnabreviadoJAMA PSYCHIATRYes_ES
dc.relation.journalJAMA Psychiatryes_ES
dc.identifier.placeEstados Unidoses_ES
dc.date.published2020es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn2168-6238es_ES
dc.identifier.doi10.1001/jamapsychiatry.2019.3501es_ES


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