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dc.creatorMagdaleno-Madrigal, Víctor Manueles_ES
dc.creatorMorales-Mulia, Sandraes_ES
dc.creatorNicolini, Humbertoes_ES
dc.creatorGenis-Mendoza, Almaes_ES
dc.creatorCázares-Martínez, Claudia Elizabethes_ES
dc.creatorPérez-Luna, José Manueles_ES
dc.creatorMorales-Mulia, Marcelaes_ES
dc.date2019
dc.date.accessioned2021-06-21T18:12:21Z
dc.date.available2021-06-21T18:12:21Z
dc.date.issued2019es_ES
dc.identifierJC004es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7464
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2018.12.037es_ES
dc.descriptionOrexins (OXs) system has been suggested to play a key role in regulate processes related to arousal, including anxious behaviors. However, until now, the contribution of OXs in anxiogenic-like effects has not been com pletely clear, particularly in rats, whose results are not yet conclusive in behavioral-tests such as elevated-plus maze test (EPM-test). The goal of this study was to explore the anxiogenic-like effect induced by orexin-A (OX-A) using two different paradigms; the EPM-test and simultaneously a quantitative index in vivo, the cortical-elec troencephalographic-(EEG)-record. This index proposes that a low-frequency domain EEG, particularly 0.5–5-Hz (delta and low portion of theta-waves), is a key indicator to evaluate anxiety levels. We also explored whether the anxious effect of OX-A could be altered by an antagonist of dopamine-D2-receptor (D2R) sulpiride (SUL). Our results showed that intracerebroventricular (i.c.v.) injection of a low dose of OX-A (140 pmol) did not increase anxiety levels in rats. On the other hand, cortical-EEG-activity showed only a decrease in delta-spectral-power but no changes in theta-potency. These data suggest that the reduction in delta-power induced by OX-A only keeps the animals awake and alert without changes in anxiety levels.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation361; 26-31 p.es_ES
dc.rightsAcceso cerradoes_ES
dc.sourceBehavioral Brain Research (0166-4328)Vol. 361 p. 26-31 (2019)es_ES
dc.titleOrexin-A promotes EEG changes but fails to induce anxiety in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationNeurofisiología del Control y la Regulación, Dirección de Neurociencias, INPRFM, México D.F., Mexicoes_ES
dc.contributor.emailmmulia@imp.edu.mx (M. Morales-Mulia).es_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.relation.journalPaíses Bajoses_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7549es_ES
dc.subject.kwOrexins system
dc.subject.kwElectroencephalographic-activity
dc.subject.kwAnxiety
dc.subject.kwDopamine-D2-receptor


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