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Orexin-A promotes EEG changes but fails to induce anxiety in rats
| dc.creator | Magdaleno-Madrigal, Víctor Manuel | es_ES |
| dc.creator | Morales-Mulia, Sandra | es_ES |
| dc.creator | Nicolini, Humberto | es_ES |
| dc.creator | Genis-Mendoza, Alma | es_ES |
| dc.creator | Cázares-Martínez, Claudia Elizabeth | es_ES |
| dc.creator | Pérez-Luna, José Manuel | es_ES |
| dc.creator | Morales-Mulia, Marcela | es_ES |
| dc.date | 2019 | |
| dc.date.accessioned | 2021-06-21T18:12:21Z | |
| dc.date.available | 2021-06-21T18:12:21Z | |
| dc.date.issued | 2019 | es_ES |
| dc.identifier | JC004 | es_ES |
| dc.identifier.issn | 0166-4328 | es_ES |
| dc.identifier.uri | http://repositorio.inprf.gob.mx/handle/123456789/7464 | |
| dc.identifier.uri | https://doi.org/10.1016/j.bbr.2018.12.037 | es_ES |
| dc.description | Orexins (OXs) system has been suggested to play a key role in regulate processes related to arousal, including anxious behaviors. However, until now, the contribution of OXs in anxiogenic-like effects has not been com pletely clear, particularly in rats, whose results are not yet conclusive in behavioral-tests such as elevated-plus maze test (EPM-test). The goal of this study was to explore the anxiogenic-like effect induced by orexin-A (OX-A) using two different paradigms; the EPM-test and simultaneously a quantitative index in vivo, the cortical-elec troencephalographic-(EEG)-record. This index proposes that a low-frequency domain EEG, particularly 0.5–5-Hz (delta and low portion of theta-waves), is a key indicator to evaluate anxiety levels. We also explored whether the anxious effect of OX-A could be altered by an antagonist of dopamine-D2-receptor (D2R) sulpiride (SUL). Our results showed that intracerebroventricular (i.c.v.) injection of a low dose of OX-A (140 pmol) did not increase anxiety levels in rats. On the other hand, cortical-EEG-activity showed only a decrease in delta-spectral-power but no changes in theta-potency. These data suggest that the reduction in delta-power induced by OX-A only keeps the animals awake and alert without changes in anxiety levels. | es_ES |
| dc.format | es_ES | |
| dc.language.iso | eng | es_ES |
| dc.publisher | Elsevier | es_ES |
| dc.relation | 361; 26-31 p. | es_ES |
| dc.rights | Acceso cerrado | es_ES |
| dc.source | Behavioral Brain Research (0166-4328)Vol. 361 p. 26-31 (2019) | es_ES |
| dc.title | Orexin-A promotes EEG changes but fails to induce anxiety in rats | es_ES |
| dc.type | Artículo | es_ES |
| dc.contributor.affiliation | Neurofisiología del Control y la Regulación, Dirección de Neurociencias, INPRFM, México D.F., Mexico | es_ES |
| dc.contributor.email | mmulia@imp.edu.mx (M. Morales-Mulia). | es_ES |
| dc.relation.jnabreviado | BEHAV BRAIN RES | es_ES |
| dc.relation.journal | Behavioural Brain Research | es_ES |
| dc.identifier.place | Países Bajos | |
| dc.date.published | 2019 | es_ES |
| dc.identifier.organizacion | Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz | es_ES |
| dc.identifier.eissn | 1872-7549 | es_ES |
| dc.subject.kw | Orexins system | |
| dc.subject.kw | Electroencephalographic-activity | |
| dc.subject.kw | Anxiety | |
| dc.subject.kw | Dopamine-D2-receptor |
