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dc.creatorSantos-Valencia, Fernandoes_ES
dc.creatorAlmazán-Alvarado, Salvadores_ES
dc.creatorRubio-Luviano, Alejandro
dc.creatorValdés-Cruz, Alejandro
dc.creatorMagdaleno-Madrigal, Victor Manuel
dc.creatorMartínez-Vargas, David
dc.date2019
dc.date.accessioned2021-04-20T19:13:54Z
dc.date.available2021-04-20T19:13:54Z
dc.date.issued2019es_ES
dc.identifierJC001es_ES
dc.identifier.issn1876-4754es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7459
dc.identifier.urihttps://doi.org/10.1016/j.brs.2019.07.016es_ES
dc.descriptionBackground: Variation in the temporal patterns of electrical pulses in stimulation trains has opened a new field of opportunity for the treatment of neurological disorders, such as pharmacoresistant temporal lobe epilepsy. Whether this novel type of stimulation affects epileptogenesis remains to be investigated. Objective: The purpose of this study was to analyze the effects of temporally irregular deep brain stimulation on kindling-induced epileptogenesis in rats. Methods: Temporally irregular deep brain stimulation was delivered at different times with respect to the kindling stimulation. Behavioral and electrographic changes on kindling acquisition were compared with a control group and a temporally regular deep brain stimulation-treated group. The propagation of epileptiform activity was analyzed with wavelet cross-correlation analysis, and interictal epileptiform discharge ratios were obtained. Results: Temporally irregular deep brain stimulation delivered in the epileptogenic focus during the interictal period shortened the daily afterdischarge duration, slowed the progression of seizure stages, diminished the generalized seizure duration and interfered with the propagation of epileptiform activity from the seizure onset zone to the ipsi- and contralateral motor cortex. We also found a negative cor relation between seizure severity and interictal epileptiform discharges in rats stimulated with temporally irregular deep brain stimulation. Conclusion: These results provide evidence that temporally irregular deep brain stimulation interferes with the establishment of epilepsy by delaying epileptogenesis by almost twice as long in kindling an imals. Thus, temporally irregular deep brain stimulation could be a preventive approach against epilepsy.es_ES
dc.formatAdobe PDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation12(6)1429-1438 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.sourceBrain stimulation Vol. 12 no. 6 p.1429-1438 (2019)es_ES
dc.subject
dc.subject.meshAnimals
dc.subject.meshDeep Brain Stimulation / methods
dc.subject.meshDisease Models, Animal
dc.subject.meshElectric Stimulation / methods
dc.subject.meshEpilepsy / physiopathology
dc.subject.meshEpilepsy / therapy
dc.subject.meshKindling, Neurologic / physiology
dc.subject.meshMale
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSeizures / physiopathology
dc.subject.meshSeizures / therapy
dc.subject.meshTime Factors
dc.titleTemporally irregular electrical stimulation to the epileptogenic focus delays epileptogenesis in ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología del Control y la Regulación, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370, Ciudad de México, Mexico.es_ES
dc.contributor.emaildavmv@imp.edu.mx.es_ES
dc.relation.jnabreviadoBRAIN STIMULes_ES
dc.relation.journalBrain Stimulationes_ES
dc.identifier.placeEstados Unidoses_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.1016/j.brs.2019.07.016.
dc.subject.kwEpilepsy
dc.subject.kwDeep brain stimulation
dc.subject.kwKindling
dc.subject.kwEpileptogenesis
dc.subject.kwTemporally irregular stimulation


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