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Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010

dc.creatorVos, Theo
dc.creatorFlaxman, Abraham D.
dc.creatorNaghavi, Mohsen
dc.creatorLozano, Rafael
dc.creatorMichaud, Catherine
dc.creatorEzzati, Majid
dc.creatorShibuya, Kenji
dc.creatorSalomón, Joshua A.
dc.creatorAbdalla, Safa
dc.creatorAboyans, Víctor
dc.creatorAbraham, Jerry
dc.creatorTaylor, William J.
dc.creatorCheng, Andrew Tai-Ann
dc.creatorFeigin, Valery
dc.creatorBudke, Christine M.
dc.creatorThomas, Bernadette
dc.creatorDharmaratne, Samath D.
dc.creatorFarzadfar, Farshad
dc.creatorThomson, W. Murray
dc.creatorThurston, George D.
dc.creatorMarks, Robín
dc.creatorTowbin, Jeff Rey A.
dc.creatorBrugha, Traolach S.
dc.creatorWhiteford, Harvey
dc.creatorSteiner, Timothy
dc.creatorBhandari, Bishal
dc.creatorTleyjeh, Imad M.
dc.creatorLoane, María
dc.creatorNaldi, Luigi
dc.creatorUbeda, Clotilde
dc.creatorGrainger, Rebecca
dc.creatorTonelli, Marcello
dc.creatorBaxter, Amanda
dc.creatorBirbeck, Gretchen
dc.creatorFinucane, Mariel M.
dc.creatorMallinger, Leslie
dc.creatorFerri, Cleusa P.
dc.creatorBaddour, Larry M.
dc.creatorBin Abdulhak, Aref
dc.creatorMerriman, Tony R.
dc.creatorWiersma, Steven T.
dc.creatorWilkinson, James D.
dc.creatorNewton, Charles R.
dc.creatorStovner, Lars Jacob
dc.creatorWilliams, Hywel C.
dc.creatorLeigh, James
dc.creatorWilliams, Sean R.M.
dc.creatorWitt, Emma
dc.creatorGroeger, Justina
dc.creatorFerrari, Alize
dc.creatorLyons, Ronan
dc.creatorNarayan, K.M. Venkat
dc.creatorEspíndola, Patricia
dc.creatorPhillips, David
dc.creatorPandian, Jeyaraj Durai
dc.creatorMeyer, Ana-Claire
dc.creatorDriscoll, Tim
dc.creatorNevitt, Michael C.
dc.creatorWolfe, Frederick
dc.creatorBurch, Michael
dc.creatorBlack, James A.
dc.creatorNelson, Paul K.
dc.creatorBlencowe, Hannah
dc.creatorBlore, Jed D.
dc.creatorBlyth, Fiona
dc.creatorBasáñez, María-Gloria
dc.creatorPorrini, Esteban
dc.creatorWeisskopf, Marc G.
dc.creatorBolliger, Ian
dc.creatorJasrasaria, Rashmi
dc.creatorDherani, Mukesh
dc.creatorGanatra, Hammad A.
dc.creatorBonaventure, Audrey
dc.creatorJarvis, Deborah
dc.creatorBoufous, Soufi Ane
dc.creatorPierce, Kelsey
dc.creatorLópez, Alan D.
dc.creatorBurney, Peter
dc.creatorTruelsen, Thomas
dc.creatorBourne, Rupert
dc.creatorNelson, Robert G.
dc.creatorLathlean, Tim
dc.creatorRonfani, Luca
dc.creatorKarthikeyan, Ganesan
dc.creatorBoussinesq, Michel
dc.creatorNorman, Rosana
dc.creatorPolinder, Suzanne
dc.creatorRivero, Andrea Panozo
dc.creatorCross, Marita
dc.creatorBurstein, Roy
dc.creatorPión, Sebastien
dc.creatorCalabria, Bianca
dc.creatorCampbell, Benjamín
dc.creatorLeasher, Janet L.
dc.creatorCanter, Charles E.
dc.creatorJohns, Nicole
dc.creatorAnderson, H. Ross
dc.creatorRoom, Robín
dc.creatorPatten, Scott B.
dc.creatorBernabe, Eduardo
dc.creatorCarabin, Helene
dc.creatorHill, Catherine
dc.creatorMalekzadeh, Reza
dc.creatorGunnell, David
dc.creatorCarapetis, Jonathan
dc.creatorAndrews, Kathryn G.
dc.creatorMacIntyre, Michael F.
dc.creatorCarmona, Loreto
dc.creatorCella, Claudia
dc.creatorRehm, Juergen T.
dc.creatorGosselin, Richard
dc.creatorDabhadkar, Kaustubh C.
dc.creatorBuchbinder, Rachelle
dc.creatorAggarwal, Rakesh
dc.creatorCharlson, Fiona
dc.creatorPolanczyk, Guilherme V.
dc.creatorSingleton, Jessica
dc.creatorCoffeng, Luc E.
dc.creatorMiller, Matthew
dc.creatorChen, Honglei
dc.creatorForeman, Kyle
dc.creatorMargolis, David J.
dc.creatorPullan, Rachel L.
dc.creatorMarcenes, Wagner
dc.creatorErskine, Holly
dc.creatorFlood, Louise
dc.creatorRosenfeld, Lisa C.
dc.creatorDahiya, Manu
dc.creatorDahodwala, Nabila
dc.creatorStapelberg, Nicolas J.C.
dc.creatorDamsere-Derry, James
dc.creatorPerico, Norberto
dc.creatorDanaei, Goodarz
dc.creatorDavis, Adrián
dc.creatorMiller, Ted R.
dc.creatorManivannan, Sivabalan
dc.creatorPope, C. Arden
dc.creatorSleet, David A.
dc.creatorMa, Jixiang
dc.creatorTsilimbaris, Miltiadis K.
dc.creatorRushton, Lesley
dc.creatorLin, John Kent
dc.creatorSmith, Jennifer L.
dc.creatorDe Leo, Diego
dc.creatorGupta, Ramyani
dc.creatorForouzanfar, Mohammad H.
dc.creatorSliwa, Karen
dc.creatorFowkes, Francis Gerry R.
dc.creatorFranklin, Richard
dc.creatorFransen, Marlene
dc.creatorWang, Wenzhi
dc.creatorCowie, Benjamín C.
dc.creatorFreeman, Michael K.
dc.creatorNorman, Paul
dc.creatorLee, Yong Yi
dc.creatorBahalim, Adil N.
dc.creatorGabbe, Belinda J.
dc.creatorNolte, Sandra
dc.creatorGabriel, Sherine E.
dc.creatorUndurraga, Eduardo A.
dc.creatorHaagsma, Juanita
dc.creatorChou, David
dc.creatorAhn, Stephanie Y.
dc.creatorSmith, Emma
dc.creatorPearce, Neil
dc.creatorWoolf, Anthony D.
dc.creatorO'Hanlon, Simón
dc.creatorGakidou, Emmanuela
dc.creatorStolk, Wilma A.
dc.creatorVavilala, Mónica S.
dc.creatorKassebaum, Nicholas
dc.creatorHagan, Holly
dc.creatorVan der Werf, Marieke J.
dc.creatorHalasa, Yara A.
dc.creatorHall, Wayne
dc.creatorPérez Padilla, Rogelio
dc.creatorHaring, Diana
dc.creatorBartels, David H.
dc.creatorEbel, Beth
dc.creatorWulf, Sarah
dc.creatorFevre, Eric M.
dc.creatorHaro, Josep Maria
dc.creatorNaidoo, Kovin
dc.creatorPrince, Martín
dc.creatorMocumbi, Ana Olga
dc.creatorHarrison, James E.
dc.creatorElbaz, Alexis
dc.creatorPourmalek, Farshad
dc.creatorHavmoeller, Rasmus
dc.creatorAlvarado, Miriam
dc.creatorMiglioli, Valeria
dc.creatorKawakami, Norito
dc.creatorGuillemin, Francis
dc.creatorDolk, Helen
dc.creatorHay, Roderick J.
dc.creatorVan Os, Jim
dc.creatorBrayne, Carol
dc.creatorHotez, Peter J.
dc.creatorSaha, Sukanta
dc.creatorHigashi, Hideki
dc.creatorRazavi, Homie
dc.creatorWeinstock, Martín A.
dc.creatorBell, Michelle L.
dc.creatorAtkinson, Charles
dc.creatorMarks, Guy B.
dc.creatorYeh, Pon-Hsiu
dc.creatorKeren, Andre
dc.creatorAnderson, Laurie M.
dc.creatorBryan-Hancock, Claire
dc.creatorKhoo, Jon-Paul
dc.creatorKing, Charles H.
dc.creatorKnowlton, Lisa Marie
dc.creatorSampson, Uchechukwu
dc.creatorRamaiah, Kapa D.
dc.creatorBikbov, Boris
dc.creatorBridgett, Lisa
dc.creatorPopova, Svetlana
dc.creatorChugh, Sumeet S.
dc.creatorZaidi, Anita K.M.
dc.creatorPhillips, Michael R.
dc.creatorKobusingye, Olive
dc.creatorMoffitt, Terrie E.
dc.creatorMatsumori, Akira
dc.creatorBrooker, Simón
dc.creatorMatzopoulos, Richard
dc.creatorMayosi, Bongani M.
dc.creatorMcAnulty, John H.
dc.creatorCooper, Leslie T.
dc.creatorJonas, Jost B.
dc.creatorMcDermott, Mary M.
dc.creatorPérez-Ruíz, Fernando
dc.creatorAckerman, Ilana
dc.creatorMcGill, Neil
dc.creatorSteer, Andrew
dc.creatorMcGrath, John
dc.creatorColan, Steven D.
dc.creatorBarker-Collo, Suzanne
dc.creatorHoen, Bruno
dc.creatorDorsey, E. Ray
dc.creatorBrooks, Peter
dc.creatorDegenhardt, Louisa
dc.creatorBhalla, Kavi
dc.creatorMedina-Mora, María Elena
dc.creatorBuckle, Geoffrey
dc.creatorCondon, John
dc.creatorOlives, Casey
dc.creatorMokdad, Ali A.
dc.creatorColquhoun, Samantha
dc.creatorMonasta, Lorenzo
dc.creatorMontico, Marcella
dc.creatorMoradi-Lakeh, Maziar
dc.creatorEwoigbokhan, Stalin E.
dc.creatorLipshultz, Steven E.
dc.creatorDellavalle, Robert
dc.creatorMarch, Lyn
dc.creatorMoran, Andrew
dc.creatorSingh, Jasvinder A.
dc.creatorWeatherall, David J.
dc.creatorSanman, Ella
dc.creatorMorawska, Lidia
dc.creatorWatt, Kerrianne
dc.creatorMori, Rintaro
dc.creatorDuber, Herbert
dc.creatorSacco, Ralph L.
dc.creatorOmer, Saad B.
dc.creatorMitchell, Philip B.
dc.creatorLim, Stephen S.
dc.creatorMurdoch, Michele E.
dc.creatorColson, K. Ellicott
dc.creatorGarcía, Bianca
dc.creatorZheng, Zhi-Jie
dc.creatorMwaniki, Michael K.
dc.creatorWeissman, Myrna M.
dc.creatorCourville de Vaccaro, Karen
dc.creatorFelson, David T.
dc.creatorAli, Suad Eltahir
dc.creatorRegan, Mathilda
dc.creatorDelossantos, Allyne
dc.creatorOrtblad, Katrina
dc.creatorEdmond, Karen
dc.creatorOsborne, Richard
dc.creatorOzgediz, Doruk
dc.creatorPage, Andrew
dc.creatorZonies, David
dc.creatorWeintraub, Robert
dc.creatorFlaxman, Seth
dc.creatorGaspari, Flavio
dc.creatorWang, Mengru
dc.creatorHoffman, Howard
dc.creatorDenenberg, Julie
dc.creatorPahari, Bishnu
dc.creatorBennett, Derrick
dc.creatorRein, David B.
dc.creatorGillum, Richard F.
dc.creatorRemuzzi, Guiseppe
dc.creatorRichardson, Kathryn
dc.creatorRivara, Frederick P.
dc.creatorJames, Spencer L.
dc.creatorO'Donnell, Martín
dc.creatorRoberts, Thomas
dc.creatorDíaz-Torne, César
dc.creatorRobinson, Carolyn
dc.creatorBucello, Chiara
dc.creatorBenjamín, Emelia J.
dc.creatorHoy, Damian
dc.creatorErwin, Patricia J.
dc.creatorBarrero, Lope H.
dc.creatorLimb, Elizabeth
dc.creatorGmel, Gerhard
dc.creatorKoranteng, Adolfo
dc.creatorRodríguez De León, Felipe
dc.creatorAli, Mohammed K.
dc.creatorJacobsen, Kathryn H.
dc.creatorSudfeld, Christopher
dc.creatorSchwebel, David C.
dc.creatorHuang, John J.
dc.creatorScott, James Graham
dc.creatorSegui-Gómez, María
dc.creatorShahraz, Saeid
dc.creatorKrishnamurthi, Rita
dc.creatorMabweijano, Jacqueline
dc.creatorRanganathan, Dharani
dc.creatorShepard, Donald S.
dc.creatorCortinovis, Mónica
dc.creatorMurray, Christopher J.L.
dc.creatorBraithwaite, Tasanee
dc.creatorShin, Hwashin
dc.creatorCorriere, Matthew
dc.creatorShivakoti, Rupak
dc.creatorLipnick, Michael
dc.creatorSánchez-Riera, Lidia
dc.creatorSyed, Sana
dc.creatorPesudovs, Konrad
dc.creatorSingh, David
dc.creatorIbeanusi, Sydney E.
dc.creatorDerrett, Sarah
dc.creatorMeltzer, Michele
dc.creatorCriqui, Michael H.
dc.creatorSingh, Gitanjali M.
dc.creatorJayaraman, Sudha
dc.creatorLockett Ohno, Summer
dc.creatorLalloo, Ratilal
dc.creatorWhite, Richard A.
dc.creatorTamburlini, Giorgio
dc.creatorLiu, Wei
dc.creatorTavakkoli, Mohammad
dc.creatorTaylor, Hugh R.
dc.creatorDes Jarlais, Don C.
dc.creatorTaylor, Jennifer A.
dc.creatorCouser, William
dc.creatorConnor, Myles D.
dc.creatorMensah, George A.
dc.creatorLaslett, Laura L.
dc.creatorNair, M. Nathan
dc.date.accessioned2017-06-30T04:05:41Z
dc.date.available2017-06-30T04:05:41Z
dc.date.issued2012
dc.identifier2499es_ES
dc.identifier.issn0140-6736es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7139
dc.identifier.urihttps://doi.org/10.1016/S0140-6736(12)61729-2es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350784/es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAes_ES
dc.relation380 (9859) 2163-2196 p.es_ES
dc.relationversión del editores_ES
dc.rightsAcceso Cerradoes_ES
dc.subject.meshNeglected tropical diseaseses_ES
dc.subject.meshAdjusted-life-yearses_ES
dc.subject.meshIron-deficiency anemiaes_ES
dc.subject.meshDeveloping-countrieses_ES
dc.subject.meshAnchoring vignetteses_ES
dc.subject.meshDepressive disorderes_ES
dc.subject.meshHearing impairmentes_ES
dc.subject.meshCognitive functiones_ES
dc.subject.meshMental-disorderses_ES
dc.subject.meshRisk-factorses_ES
dc.titleYears lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010es_ES
dc.typeArticlees_ES
dc.contributor.affiliationUniv Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.es_ES
dc.contributor.emailcjlm@uw.edues_ES
dc.relation.jnabreviadoLANCETes_ES
dc.relation.journalLancetes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1474-547Xes_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaBackground Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs). Methods Of the 291 diseases and injuries in the GBD cause list, 289 cause disability. For 1160 sequelae of the 289 diseases and injuries, we undertook a systematic analysis of prevalence, incidence, remission, duration, and excess mortality. Sources included published studies, case notification, population-based cancer registries, other disease registries, antenatal clinic serosurveillance, hospital discharge data, ambulatory care data, household surveys, other surveys, and cohort studies. For most sequelae, we used a Bayesian meta-regression method, DisMod-MR, designed to address key limitations in descriptive epidemiological data, including missing data, inconsistency, and large methodological variation between data sources. For some disorders, we used natural history models, geospatial models, back-calculation models (models calculating incidence from population mortality rates and case fatality), or registration completeness models (models adjusting for incomplete registration with health-system access and other covariates). Disability weights for 220 unique health states were used to capture the severity of health loss. YLDs by cause at age, sex, country, and year levels were adjusted for comorbidity with simulation methods. We included uncertainty estimates at all stages of the analysis. Findings Global prevalence for all ages combined in 2010 across the 1160 sequelae ranged from fewer than one case per 1 million people to 350 000 cases per 1 million people. Prevalence and severity of health loss were weakly correlated (correlation coefficient -0.37). In 2010, there were 777 million YLDs from all causes, up from 583 million in 1990. The main contributors to global YLDs were mental and behavioural disorders, musculoskeletal disorders, and diabetes or endocrine diseases. The leading specific causes of YLDs were much the same in 2010 as they were in 1990: low back pain, major depressive disorder, iron-deficiency anaemia, neck pain, chronic obstructive pulmonary disease, anxiety disorders, migraine, diabetes, and falls. Age-specific prevalence of YLDs increased with age in all regions and has decreased slightly from 1990 to 2010. Regional patterns of the leading causes of YLDs were more similar compared with years of life lost due to premature mortality. Neglected tropical diseases, HIV/AIDS, tuberculosis, malaria, and anaemia were important causes of YLDs in sub-Saharan Africa. Interpretation Rates of YLDs per 100 000 people have remained largely constant over time but rise steadily with age. Population growth and ageing have increased YLD numbers and crude rates over the past two decades. Prevalences of the most common causes of YLDs, such as mental and behavioural disorders and musculoskeletal disorders, have not decreased. Health systems will need to address the needs of the rising numbers of individuals with a range of disorders that largely cause disability but not mortality. Quantification of the burden of non-fatal health outcomes will be crucial to understand how well health systems are responding to these challenges. Effective and affordable strategies to deal with this rising burden are an urgent priority for health systems in most parts of the world.es_ES


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