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Treatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover study

dc.creatorMontes, L.G.A.
dc.creatorUribe, M.P.O.
dc.creatorSotres, J.C.
dc.creatorMartín, G.H.
dc.date.accessioned2017-06-30T04:04:58Z
dc.date.available2017-06-30T04:04:58Z
dc.date.issued2003es_ES
dc.identifier2494es_ES
dc.identifier.issn1180-4882es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7135
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/12790159/es_ES
dc.language.isoenges_ES
dc.publisherCANADIAN MEDICAL ASSOCIATION, 1867 ALTA VISTA DR, OTTAWA, ONTARIO K1G 3Y6, CANADAes_ES
dc.relation28 (3) 191-196 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTreatment of primary insomnia with melatonin: a double-blind, placebo-controlled, crossover studyes_ES
dc.typearticlees_ES
dc.contributor.affiliationNatl Inst Psychiat, Calzada Mexico Xochimilco 101 san Lorenzo Huipulc, Mexico City 14370, DF, Mexico.es_ES
dc.relation.jnabreviadoJ PSYCHIATRY NEUROSCIes_ES
dc.relation.journalJournal of psychiatry and neurosciencees_ES
dc.identifier.placeOntarioes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1488-2434es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaObjective: To assess the hypnotic effect of melatonin in patients with primary insomnia. Method: Ten patients (mean age 50 yr, range 30-72 yr) who met the DSM-IV criteria for primary insomnia received, in random order, 0.3 mg of melatonin, 1.0 mg of melatonin or placebo 60 minutes before bedtime. A crossover design was used so that each patient received each of the 3 treatments for a 7-day period (with a 5-day washout period between). After each 7-day treatment, night time electroencephalographic (EEG) records were collected, and each morning, subjects completed sleep logs and analogue-visual scales to document the amount and subjective quality of sleep. Results: There were no significant differences in sleep EEG, the amount or subjective quality of sleep or side effects between the placebo, 0.3-mg melatonin or 1.0-mg melatonin treatments. Conclusion: Melatonin did not produce any sleep benefit in this sample of patients with primary insomnia.es_ES


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