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Synergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin test

dc.creatorMontiel-Ruíz, Rosa Mariana
dc.creatorGonzález-Trujano, María Eva
dc.creatorDeciga-Campos, Myrna
dc.date.accessioned2017-06-30T04:03:57Z
dc.date.available2017-06-30T04:03:57Z
dc.date.issued2013es_ES
dc.identifier2483es_ES
dc.identifier.issn0944-7113es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7124
dc.identifier.urihttps://doi.org/10.1016/j.phymed.2013.07.006es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG, OFFICE JENA, P O BOX 100537, 07705 JENA, GERMANYes_ES
dc.relation20 (14) 1280-1287 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleSynergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin testes_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Politecn Nacl, Secc Estudios Posgrad & Invest, Escuela Super Med, Mexico City 11340, DF, Mexicoes_ES
dc.contributor.emailmyrnadeciga@hotmail.comes_ES
dc.relation.jnabreviadoPHYTOMEDICINEes_ES
dc.relation.journalPhytomedicinees_ES
dc.identifier.placeJenaes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1618-095Xes_ES
dc.identifier.doi10.1016/j.phymed.2013.07.006es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaAim: In this study, the pharmacological interactions between a Rhodiola rosea ethanol extract and B-vitamins such as thiamine (B-1), riboflavine (B-2), pyridoxine (B-6), cyanocobalamin (B-12) and a mixture of vitamins B-1 + B-6 + B-12 was investigated in the mouse formalin test. Methods: Individual dose response curves of the Rhodiola rosea ethanol extract, as well as B-vitamins alone or in a mixture were evaluated in mice in which nociception was induced with 2% formalin intraplantarly. The antinociceptive mechanisms of the Rhodiola rosea were investigated by exploring the role of the opioid and serotonin receptors and the nitric oxide pathway. Isobolographic analysis was used to evaluate the pharmacological interactions between the Rhodiola rosea ethanol extract and each B-vitamin individually or the mixture of vitamins B-1 + B-6 + B-12 by using the ED30 and a fixed 1:1 ratio combination. Results: Administration of the Rhodiola rosea extract alone or in combination with all of the vitamins produced a significant and dose-dependent antinociceptive response. The antinociceptive effect of the Rhodiola rosea extract (ED50 = 81 mg/kg, p.o.) was significant and reverted in the presence of antagonists of the 5-HT1A, GABA/BDZs and opioid receptors and by blocking mediators of the nitric oxide/cGMP/K+ channels pathway. Isobolograms demonstrate that all of the combinations investigated in this study produced a synergistic interaction experimental ED30 values were significantly smaller than those calculated theoretically. Conclusions: These results provide evidence that a Rhodiola rosea ethanol extract in combination with B-vitamins produces a significant diminution in the nociceptive response in a synergistic manner, which is controlled by various mechanisms. These findings could aid in the design of clinical studies and suggest that these combinations could be applied for pain therapy. (C) 2013 Elsevier GmbH. All rights reserved.es_ES


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