Mostrar el registro sencillo del ítem

Participation of estrogen receptors in the antidepressant-like effect of prolame on the forced swimming test

dc.creatorLemini, C.
dc.creatorCruz-Lopez, B.
dc.creatorMartínez-Mota, L.
dc.date.accessioned2017-06-30T04:01:05Z
dc.date.available2017-06-30T04:01:05Z
dc.date.issued2013es_ES
dc.identifier2453es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7094
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.11.004es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation103 (3) 659-665 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleParticipation of estrogen receptors in the antidepressant-like effect of prolame on the forced swimming testes_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Nacl Autonoma Mexico, Dept Farmacol, Fac Med, Mexico City 04360, DF, Mexicoes_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, biochemistry, and behaviores_ES
dc.identifier.placeOxfordes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2012.11.004es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaEstrogen therapy may produce antidepressant-like actions, but the side effects, such as thromboembolic events, may restrict its use among women. The 17 beta-aminoestrogens (AEs) [prolame [17 beta-(3-hidroxy-1-propylamino)-1,3,5(10)-estratrien-3-ol)1, butolame [17 beta-(3-hidroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol)], and pentolame [17 beta-(5-hidroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol)] induce estrogenic and anticoagulant actions, effects that could prove advantageous in an estrogen therapy| however, their antidepressant-like effects have not been described. The objective of this study was to determine the effect of these 17 beta-AEs (prolame, butolame and pentolame) in the forced swimming test (FST), an animal model sensitive to antidepressant drugs, and to establish the role of estrogen receptors in such actions. Ovariectomized female rats treated with prolame (10-200 mu g/rat) showed a reduction in immobility and an increase in active behaviors in the FST, while this effect was not produced by butolame and pentolame (10-200 mu g/rat). The antidepressant-like effect of prolame was similar to that of 17 beta-estradiol (E2, 5-20 mu g/rat), sharing with it a biphasic profile but at higher doses. Antidepressant-like actions of prolame and E2 were not associated with changes in locomotor activity. With respect to a control group tamoxifen (15 mg/kg) by itself produced no changes in all behavioral evaluations, but canceled the antidepressant-like effect of prolame and E2. It is concluded that estrogen receptors participate in antidepressant-like effect of both estrogens in the FST. Antidepressant-like activity of different AEs is discussed considering their differences in chemical structure and the schedule used. Our results show additional central actions of prolame besides its pro-sexual, anti-coagulant, estrogenic and anxiolytic activity. (c) 2012 Elsevier Inc. All rights reserved.es_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem