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Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist

dc.creatorMiranda-Cardenas, Yuritzia
dc.creatorRojas-Piloni, Gerardo
dc.creatorMartínez-Lorenzana, Guadalupe
dc.creatorRodríguez-Jiménez, Javier
dc.creatorLópez-Hidalgo, Mónica
dc.creatorFreund-Mercier, Marie José
dc.creatorCondés-Lara, Miguel
dc.date.accessioned2017-06-30T04:00:56Z
dc.date.available2017-06-30T04:00:56Z
dc.date.issued2006es_ES
dc.identifier2451es_ES
dc.identifier.issn0304-3959es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7092
dc.identifier.urihttp://doi.org/10.1016/j.pain.2006.01.029es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSes_ES
dc.relation122 (1-2) 182-189 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleOxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonistes_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Nacl Autonoma Mexico, Inst Neurobiol, Campus Juriquilla, Queretaro, Mexicoes_ES
dc.contributor.emailcondes@servidor.unam.mxes_ES
dc.relation.jnabreviadoPAINes_ES
dc.relation.journalPaines_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-6623es_ES
dc.identifier.doi10.1016/j.pain.2006.01.029es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaIn recent years, oxytocin has been implicated in a wide diversity of functions. The role of oxytocin in analgesia and pain modulation represents an important new function of an endogenous system controlling sensorial information. The paraventricular (PV) nucleus of the hypothalamus is one of the most important sources of oxytocin, and it has a very well-defined projection to the spinal cord. The location of this PV spinal cord projection correlates well with oxytocin binding sites at the dorsal horn of the spinal cord. In this work, we used rats with a chronic (46 days) sciatic loose ligature, an electrical stimulating electrode, and an intrathecal cannula, which reached the L4-L5 levels of the spinal cord. We compared the oxytocin effects with electrical stimulation of the PV and observed a significant reduction of the withdrawal responses to mechanical and cold stimulation applied to the ipsilateral and contralateral hind paws. An oxytocin antagonist administered intrathecally blocked the PV effects. Naloxone was also intrathecally injected 2 min before the PV stimulation, and we also observed a significant reduction of the withdrawal responses| however, this reduction was less pronounced. Our results support the hypothesis that oxytocin is part of the descending inhibitory control mechanisms having an important antinociceptive action. We cannot exclude a minor opiate participation in the OT action. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.es_ES


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