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ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing

dc.creatorMonteillet-Agius, G.
dc.creatorFein, J.
dc.creatorAntón, B.
dc.creatorEvans, C.J.
dc.date.accessioned2017-06-30T04:00:51Z
dc.date.available2017-06-30T04:00:51Z
dc.date.issued1998es_ES
dc.identifier2450es_ES
dc.identifier.issn0021-9967es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7091
dc.identifier.urihttps://doi.org/10.1002/(SICI)1096-9861(19980928)399:3<373::AID-CNE6>3.0.CO;2-Yes_ES
dc.language.isoenges_ES
dc.publisherWILEY-LISS, DIV JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 USAes_ES
dc.relation399 (3) 373-383 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processinges_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Calif Los Angeles, Inst Neuropsychiat, Dept Psychiat & Biobehav Sci, 760 Westwood Plaza, Los Angeles, CA 90024 USA.es_ES
dc.relation.jnabreviadoJ COMP NEUROLes_ES
dc.relation.journalThe Journal of comparative neurologyes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1096-9861es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaMu opioid receptors (MOR) mediate the analgesic effects of opioid drugs such as morphine. The opioid receptor-like (ORL-1) receptor is structurally related to opioid receptors and the ORL-1 receptor agonist, orphanin FQ/nociceptin, induces analgesia at the spinal level, but appears to recruit different circuitry than that used by mu opioids. When administered intracerebroventricularly, orphanin FQ/nociceptin produces hyperalgesia and/or reverses opioid analgesia. The functionally distinct actions elicited by MOR and ORL-1 receptors, which activate similar intracellular signaling systems and show similar regional distributions, could be explained by their differential cellular localization. By using double label immunohistochemistry and confocal microscopy, the present study investigates the distribution of MOR and ORL-1 receptors in regions of the rat nervous system that are involved with nociceptive processing. In general co-localization of MOR and ORL-1 receptor immunoreactivity was not observed in either perikarya or neuropil in the dorsal root ganglia, nor in the Lissauer's tract and superficial laminae of the spinal cord. Likewise, there was no evidence for co-localization of these receptors within the periaqueductal gray, the nucleus raphe magnus, the gigantocellular reticular nucleus, and the nucleus of the solitary tract. These observations indicate that MOR and ORL-1 receptors are expressed predominantly on different fiber systems in these regions. This differential distribution is consistent with the distinct pharmacology of ORL-1 and MOR receptor agonists and suggests that the antisera to MOR and ORL-1 receptors may provide useful markers for further investigations of analgesic and counteranalgesic pathways modulating pain perception. (C) 1988 Wiley-Liss, Inc.es_ES


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