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Melatonin modulates cytoskeletal organization in the rat brain hippocampus

dc.creatorJiménez-Rubio, Graciela
dc.creatorOrtíz-López, Leonardo
dc.creatorBenítez-King, Gloria
dc.date.accessioned2017-06-30T03:59:26Z
dc.date.available2017-06-30T03:59:26Z
dc.date.issued2012es_ES
dc.identifier2434es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7075
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2012.01.040es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ireland LTD, Elsevier House, Brookvale Plaza, East Park Shannon, CO, Clare, 00000, Irelandes_ES
dc.relation511 (1) 47-51 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMelatonin modulates cytoskeletal organization in the rat brain hippocampuses_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria Ramon Fuente Muniz, SIC, Depto Neurofarmacol, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailbekin@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience letterses_ES
dc.identifier.placeClarees_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7972es_ES
dc.identifier.doi10.1016/j.neulet.2012.01.040es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaMelatonin concentration in plasma reaches high levels during the night and synchronizes body rhythms with the photoperiod. Previous evidence obtained in cultured cells suggests that melatonin synchronizes cytoskeletal re-arrangements at nocturnal plasma concentration. In this study, we determined the amount of microtubules and microfilaments in the rat hippocampus as an index of cytoskeletal organization in rats submitted to a photoperiodic regime. Additionally, these parameters were determined in control rats, sham rats, pinealectomized rats, and rats that were pinealectomized and treated with melatonin for 1 week. The results showed an increase in both the amount of microfilaments in the hippocampus of rats sacrificed in the dark phase, and in melatonin levels. In addition, a decrease in both microfilament and microtubule amounts occurred in pinealectomized rats. In contrast, melatonin treatment partially reestablished actin and tubulin proportions organized in microfilaments and microtubules, respectively. The results indicate that actin organization in microfilaments was associated with both the photoperiod and with melatonin levels. Together, the data support that cytoskeletal organization is regulated rhythmically by melatonin in synchrony with the photoperiod. (C) 2012 Elsevier Ireland Ltd.es_ES


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