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Low frequency stimulation modifies receptor binding in rat brain

dc.creatorLópez-Meraz, M.L.
dc.creatorNeri-Bazan, L.
dc.creatorRocha, L.
dc.date.accessioned2017-06-30T03:59:07Z
dc.date.available2017-06-30T03:59:07Z
dc.date.issued2004es_ES
dc.identifier2431es_ES
dc.identifier.issn0920-1211es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7072
dc.identifier.urihttps://doi.org/10.1016/j.eplepsyres.2004.02.005es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSes_ES
dc.relation59 (2-3) 95-105 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLow frequency stimulation modifies receptor binding in rat braines_ES
dc.typearticlees_ES
dc.contributor.affiliationIPN, Ctr Invest & Estudios Avanzados, Dept Farmacobiol, Sede Sur Tenorios 235,Col Granjas Coapa, Mexico City 14330, DF, Mexico.es_ES
dc.contributor.emaillrocha@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoEPILEPSY RESes_ES
dc.relation.journalEpilepsy researches_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-6844es_ES
dc.identifier.doi10.1016/j.eplepsyres.2004.02.005es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaExperiments were designed to reproduce the antiepileptic effects of low frequency stimulation (LFS) during the amygdala kindling process and to examine LFS-induced changes in receptor binding levels of different neurotransmitters in normal brain. Male Wistar rats were stereotactically implanted in the right amygdala with a bipolar electrode. Rats (n = 14) received twice daily LFS (15 min train of 1 Hz, 0.1 ms at an intensity of 100 to 400 muA) immediately after amygdala kindling stimulation (1 s train of 60 Hz biphasic square waves, each 1 ms at amplitude of 200-500 muA) during 20 days. The LFS suppressed epileptogenesis (full attainment of stage V kindling) but not the presence of partial seizures (lower stages of kindling) in 85.7% of the rats. Thereafter, normal rats (n = 7) received amygdala LFS twice daily for 40 trials. Animals were sacrificed 24h after last stimulation and their brain used for labeling mu opioid, benzodiazepine (BZD), alpha(1)-adrenergic, and adenylyl cyclase binding. Autoradiography experiments revealed increased BZD receptor binding in basolateral amygdala (20.5%) and thalamus (29.3%) ipsilateral to the place of stimulation and in contralateral temporal cortex (18%) as well as decreased values in ipsilateral frontal cortex (24.2%). Concerning mu receptors, LFS decreased binding values in ipsilateral sensorimotor (7.2%) and temporal (5.6%) cortices, dentate gyrus (5.8% ipsi and 6.8% contralateral, respectively), and contralateral CA1 area of dorsal hippocampus (5.5%). LFS did not modify at receptor and adenylyl cyclase binding values. These findings suggest that the antiepileptic effects of LFS may involve activation of GAGA-BZD and endogenous opioid systems. (C) 2004 Elsevier B.V. All rights reserved.es_ES


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