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High-dose naloxone (1.0 mg/kg): Psychological and endocrine effects in normal male subjects pretreated with one milligram of dexamethasone

dc.creatorMartín-Del-Campo, A.F.
dc.creatorCortés-Sotres, J.
dc.creatorHerrera-Ferre, K.
dc.creatorUlloa-Aguirre, A.
dc.date.accessioned2017-06-30T03:57:39Z
dc.date.available2017-06-30T03:57:39Z
dc.date.issued1998es_ES
dc.identifier2411es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7053
dc.identifier.urihttps://doi.org/10.1016/S0306-4530(98)00002-Xes_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation23 (4) 413-424 g.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleHigh-dose naloxone (1.0 mg/kg): Psychological and endocrine effects in normal male subjects pretreated with one milligram of dexamethasonees_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Nacl Autonoma Mexico, Hosp Gen Mexico, Fac Med, Unidad Med Expt,Clin Trastornos Sueno, Dr Balmis 148,Col Doctores, Mexico City 06726, DF, Mexico.es_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeOxfordes_ES
dc.date.published1998es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/S0306-4530(98)00002-Xes_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe possible participation of the endogenous opioid system (EOS) in the negative feedback of the hypothalamic-pituirary-adrenal axis (HPA-a) activated by low doses (1 mg) of dexamethasone (Dex) was investigated. Ten male healthy subjects (mean age 31.5 +/- 1.9 SEM) were studied on 2 separate days, in a double-blind, cross-over and placebo-controlled design. All subjects were pretreated with 1.0 mg Dex orally the night (2300h) before both test days. On the study days, subjects were admitted at 0700h for cannula insertion| the administration of an IV bolus of either naloxone (Nal) (1.0 mg/kg) or saline solution (Sal) IV was started at 0900h. Before and following each infusion, mood was measured by a Visual Analogue Scales (VAS) and by the Affective Quality Scale (AQS) every 30 min and blood samples were taken at 15-min intervals. Blood pressure and heart rate were also monitored. Before Dex administration, plasma cortisol levels were within the normal range in all subjects (210.4 +/- 13 ng/ml), while after 9 h after Dex cortisol levels showed the expected significant (p < 0.01) decrease (11.5 +/- 1.9 and 15.04 +/- 0.7 ng/ml for Sal and Nal test days respectively). There were no detectable increases in plasma cortisol levels following either Nal nor Sal administration. However, there was a Nal-induced significant increase in LH (p < 0.01) thus indicating that an effective opioid blockade at the level of the hypothalamic-pituitary unit occurred. There were also a mild and selective Dex + Nal-induced dysphoric (mood factors related to subjects perception of their cognition) and bradycardic effects (p < 0.05). These results suggest that the EOS is not directly involved in the negative feedback triggered by low doses of Dex of the HPA-a, and that there might be a possible glucocorticoid-opioid interaction for the modulation of some aspects of mood. (C) 1998 Elsevier Science Ltd. All rights reserved.es_ES


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