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Genetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patients

dc.creatorMartínez-Levy, Gabriela
dc.creatorDíaz-Galvis, John
dc.creatorBriones-Velasco, Magdalena
dc.creatorGómez-Sánchez, Ariadna
dc.creatorDe la Peña-Olvera, Francisco
dc.creatorSosa-Mora, Liz
dc.creatorPalacios-Cruz, Lino
dc.creatorRicardo-Garcell, Josefina
dc.creatorReyes-Zamorano, Ernesto
dc.creatorCruz-Fuentes, Carlos
dc.date.accessioned2017-06-30T03:57:35Z
dc.date.available2017-06-30T03:57:35Z
dc.date.issued2009es_ES
dc.identifier2410es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7052
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2009.01.004es_ES
dc.language.isoenges_ES
dc.publisherElsevier Ireland LTD, Elsevier House, Brookvale Plaza, East Park Shannon, CO, Clare, 00000, Irelandes_ES
dc.relation451 (3) 257-260 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleGenetic interaction analysis for DRD4 and DAT1 genes in a group of Mexican ADHD patientses_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiat Ramon de la Fuente Muniz, Clin Res Branch, Psychiat Genet Dept, Lab Genet Psiquiat,Subdirecc Invest Clin, Calzada Mexicoxochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailcruz@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience letterses_ES
dc.identifier.placeClarees_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7972es_ES
dc.identifier.doi10.1016/j.neulet.2009.01.004es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaAttention-deficit hyperactivity disorder (ADHD) is a clinically complex and multifactorial psychiatric disorder of inattention, hyperactivity and impulsivity. Family. twin and adoption studies suggest a genetic influence in the etiology of ADHD. Two variable number of tandem repeats (VNTR) polymorphic systems have been frequently associated with this disorder: the 7 repeat (R) allele in exon 3 of the dopamine receptor D4 (DRD4) and the 10R allele located in the 3' untranslated region (UTR) of the dopamine transporter (DAT1). We conducted a case-control association study between ADHD and these polymorphisms in a group of adolescent inhabitants of the metropolitan area of Mexico City. In addition, we evaluated the interaction between these genes, the disorder and its associated psychiatric comorbidities. No positive association between ADHD and the 7R allele of DRD4 or the 10R allele of DAT1 was observed| however, compared to controls, patients with internalized comorbidities had a lesser frequency of genotypes with the 7R allele of DRD4 and the 10/10 genotype of DAT1. A logistic regression analysis showed that the simultaneous absence of the 10/10 DAT1 and 7/7 DRD4 genotypes predicts membership to the group of ADHD patients with internalized comorbidities (e.g. anxiety, depression). Our results highlight the importance of cross-ethnic research and the possibility of a distinct genetic basis that underlies the type of comorbidities associated with ADHD. This result should be considered in terms of the Study design, and further replication is necessary in an independent sample. (C) 2009 Elsevier Ireland Ltd. All rights reserved.es_ES
dc.subject.kwTrastorno de hiperactividad y déficit de atenciónes_ES
dc.subject.kwGen del receptor de dopamina D4es_ES
dc.subject.kwGen transportador de dopaminaes_ES
dc.subject.kwInteracción genéticaes_ES
dc.subject.kwComorbilidades internalizados y externalizadoses_ES
dc.subject.kwMexicanoes_ES
dc.subject.koAttention deficit hyperactivity disorderes_ES
dc.subject.koDopamine D4 receptor genees_ES
dc.subject.koDopamine transporter genees_ES
dc.subject.koGenetic interactiones_ES
dc.subject.koInternalized and externalized comorbiditieses_ES
dc.subject.koMexicanes_ES


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