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Exhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT.

dc.creatorCarro-Juárez, M.
dc.creatorRodríguez-Manzo, G.
dc.date.accessioned2017-06-30T03:57:15Z
dc.date.available2017-06-30T03:57:15Z
dc.date.issued2001es_ES
dc.identifier2405es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7048
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(00)00327-2es_ES
dc.language.isoenges_ES
dc.publisherAmsterdam, Elsevier/North-Holland Biomedical Presses_ES
dc.relation118 (2) 161-168 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino) tetralin-Pharmacologyes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshCopulation-Physiologyes_ES
dc.subject.meshDecerebrate State-Physiopathologyes_ES
dc.subject.meshElectromyographyes_ES
dc.subject.meshEvoked Potentials-Physiologyes_ES
dc.subject.meshMalees_ES
dc.subject.meshMovement-Physiologyes_ES
dc.subject.meshPiperazines-Pharmaologyes_ES
dc.subject.meshPyridines-Pharmacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshReceptors, Serotonin-Drug effectses_ES
dc.subject.meshReceptors, Serotonin, 5-HT1es_ES
dc.subject.meshRéflex-Physiologyes_ES
dc.subject.meshSerotonin Receptor Agonists-Pharmacologyes_ES
dc.subject.meshPiperazineses_ES
dc.subject.meshPyridineses_ES
dc.subject.meshReceptors, Serotonines_ES
dc.subject.meshReceptors, Serotonin, 5-HT1es_ES
dc.subject.meshSerotonin Receptor Agonistses_ES
dc.subject.meshN-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamidees_ES
dc.subject.mesh8-Hydroxy-2-(di-n-propylamino) tetralines_ES
dc.titleExhaustion of the coital reflex in spinal male rats is reversed by the serotonergic agonist 8-OH-DPAT.es_ES
dc.typearticlees_ES
dc.contributor.affiliationUnidad de Posgrado, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, C.P.90000, AP.37 Tlaxcala, Mexicoes_ES
dc.contributor.emailroma@neuroserver.imp-neuro.edu.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1872-7549es_ES
dc.identifier.doi10.1016/S0166-4328(00)00327-2es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaPrevious studies from our laboratory have shown that the genital motor pattern associated to the coital reflex in spinal male rats becomes exhausted when repeatedly evoked. Exhaustion of the genital motor pattern could be related to the sexual exhaustion phenomenon observed in copulating male rats. The present study was aimed to describe the features of coital reflex exhaustion and to determine if the 5-HT1A agonist 8-OH-DPAT was able to reverse exhaustion of this ejaculatory-like response. Additionally, the effect of pre-treatment with the 5-HT1A antagonist WAY 100635 on the 8-OH-DPAT induced motor response was evaluated. Results revealed that development of coital reflex exhaustion initiated with a progressive increase in the latency of response and was characterised by a change in the properties of the motor pattern itself. Once exhausted, i.v. administration of 8-OH-DPAT provoked the immediate expression of a potent motor pattern similar to the coital reflex, but in the absence of urethral stimulation. Injection of WAY 100635 induced, per se, expression of the coital reflex after exhaustion. Notwithstanding, pre-treatment with WAY 100635 was able to block the 8-OH-DPAT-induced motor response implying that its effect was exerted upon 5-HT1A receptors. Data suggest that the sexual exhaustion phenomenon might possess a spinal componentes_ES


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