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Effects of the novel antidepressant S-adenosyl-methionine on alpha 1- and beta-adrenoceptors in rat brain.

dc.creatorCohen, Bruce M.
dc.creatorStramentinoli, Giorgio
dc.creatorSosa, Ana L.
dc.creatorBabb, Suzann M.
dc.creatorOlgiati, Vincenzo
dc.date.accessioned2017-06-30T03:55:22Z
dc.date.available2017-06-30T03:55:22Z
dc.date.issued1989es_ES
dc.identifier2379es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7022
dc.identifier.urihttps://doi.org/10.1016/0014-2999(89)90540-2es_ES
dc.language.isoenges_ES
dc.publisherAmsterdam : Elsevier Sciencees_ES
dc.relation170 (3) 201-207 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents-Pharmacologyes_ES
dc.subject.meshBrain Chemistry-Drug effectses_ES
dc.subject.meshImipramine-Pharmacologyes_ES
dc.subject.meshKineticses_ES
dc.subject.meshMalees_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Inbred Strainses_ES
dc.subject.meshReceptors, Adrenergic, alpha - Drug effectses_ES
dc.subject.meshReceptors, Adrenergic, beta-Drug effectses_ES
dc.subject.meshS-Adenosylmethionine-Pharmacologyes_ES
dc.subject.meshSubstanceses_ES
dc.subject.meshAntidepressive Agentses_ES
dc.subject.meshReceptors, Adrenergic, alphaes_ES
dc.subject.meshReceptors, Adrenergic, betaes_ES
dc.subject.meshS-Adenosylmethioninees_ES
dc.subject.meshImipraminees_ES
dc.titleEffects of the novel antidepressant S-adenosyl-methionine on alpha 1- and beta-adrenoceptors in rat brain.es_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratories for Psychiatric Research, McLean Hospital, Belmont, MA 02178es_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean journal of pharmacologyes_ES
dc.identifier.placePaíses Bajoses_ES
dc.date.published1989es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1879-0712es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaalpha 1- and beta-adrenoceptors were studied ex vivo in the brains of rats receiving repeated daily treatment with the standard antidepressant imipramine or the atypical antidepressant S-adenosyl-L-methionine (SAM), which has minimal effects on monoamine reuptake or turnover. Consistent with past studies, a decrease in the density of beta receptors at three weeks and an increase in the affinity of alpha 1 receptors for the agonist phenylephrine at one week of treatment was observed with imipramine. By comparison, an increase in the density of beta receptors and a decrease in the affinity of alpha 1 receptors for phenylephrine was observed at one week of treatment with SAM. These changes were no longer apparent at three weeks of treatment. The results suggest that treatment with SAM does lead to changes in adrenergic neurotransmission, but that down regulation of beta receptors or increased agonist affinity of alpha 1 receptors may not be necessary for the production of antidepressant effects.es_ES


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