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Effects of hippocampal high-frequency electrical stimulation in memory formation and their association with amino acid tissue content and release in normal rats

dc.creatorLuna-Munguia, Hiram
dc.creatorMeneses, Alfredo
dc.creatorPena-Ortega, Fernando
dc.creatorGaona, Andrés
dc.creatorRocha, Luisa
dc.date.accessioned2017-06-30T03:55:13Z
dc.date.available2017-06-30T03:55:13Z
dc.date.issued2012es_ES
dc.identifier2377es_ES
dc.identifier.issn1050-9631es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7020
dc.identifier.urihttps://doi.org/10.1002/hipo.20868es_ES
dc.language.isoenges_ES
dc.publisherWILEY-BLACKWELL, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USAes_ES
dc.relation22 (1) 98-105 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of hippocampal high-frequency electrical stimulation in memory formation and their association with amino acid tissue content and release in normal ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationCtr Res & Adv Studies, Dept Pharmacobiol, Mexico City, DF, Mexicoes_ES
dc.contributor.emaillrocha@cinvestav.mxes_ES
dc.relation.jnabreviadoHIPPOCAMPUSes_ES
dc.relation.journalHippocampuses_ES
dc.identifier.placeMaldenes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1098-1063es_ES
dc.identifier.doi10.1002/hipo.20868es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaHippocampal high frequency electrical stimulation (HFS) at 130 Hz has been proposed as a therapeutical strategy to control neurological disorders such as intractable temporal lobe epilepsy (TLE). This study was carried out to determine the effects of hippocampal HFS on the memory process and the probable involvement of amino acids. Using the autoshaping task, we found that animals receiving hippocampal HFS showed augmented short-term, but not long-term memory formation, an effect blocked by bicuculline pretreatment and associated with enhanced tissue levels of amino acids in hippocampus. In addition, microdialysis experiments revealed high extracellular levels of glutamate, aspartate, glycine, taurine, and alanine during the application of hippocampal HFS. In contrast, GABA release augmented during HFS and remained elevated for more than 1 h after the stimulation was ended. HFS had minimal effects on glutamine release. The present results suggest that HFS has an activating effect on specific amino acids in normal hippocampus that may be involved in the enhanced short-term memory formation. These data further provide experimental support for the concept that hippocampus may be a promising target for focal stimulation to treat intractable seizures in humans. (C) 2010 Wiley Periodicals, Inc., Inc.es_ES


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