Mostrar el registro sencillo del ítem

Effects of acute ethanol administration on methionine-enkephalin expression and release in regions of the rat brain

dc.creatorMéndez, M.
dc.creatorBarbosa-Luna, I.G.
dc.creatorPérez-Luna, J.M.
dc.creatorCupo, A.
dc.creatorOikawa, J.
dc.date.accessioned2017-06-30T03:55:02Z
dc.date.available2017-06-30T03:55:02Z
dc.date.issued2010es_ES
dc.identifier2375es_ES
dc.identifier.issn0143-4179es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7018
dc.identifier.urihttps://doi.org/10.1016/j.npep.2010.05.001es_ES
dc.language.isoenges_ES
dc.publisherChurchill Livingstone, Journal Production Dept, Robert Stevenson House, 1-3 Baxters Place, Leith Walk, Edinburgh EH1 3AF, Midlothian, Scotlandes_ES
dc.relation44 (5) 413-420 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEffects of acute ethanol administration on methionine-enkephalin expression and release in regions of the rat braines_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria Ramon Fuente, Dept Neuroquim, Subdirecc Invest Clin, Col San Lorenzo Huipulco, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailubach@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROPEPTIDESes_ES
dc.relation.journalNeuropeptideses_ES
dc.identifier.placeMidlothianes_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1532-2785es_ES
dc.identifier.doi10.1016/j.npep.2010.05.001es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaThe dopaminergic mesolimbic system plays a key role in mediating the reinforcing properties of ethanol and other drugs of abuse. Ethanol reinforcement and high alcohol drinking behaviour have been suggested to involve the ethanol-induced activation of endogenous opioid systems. Ethanol may alter opioidergic transmission at different levels, including opioid peptide biosynthesis and release, as well as binding to opioid receptors. The aim of this work was to investigate the effects of different ethanol doses on methionine-enkephalin (Met-enk) release from the rat nucleus accumbens (NAcc). Ethanol effects were also studied on Met-enk content in the NAcc, prefrontal cortex (PFC) and caudate-putamen (CP). Met-enk release was studied by microdialysis in Wistar anesthetized rats and peptide concentrations were quantitated by radioimmunoassay. Ethanol was administered by intraperitoneal injection after a 2-h basal release period. Ethanol doses of 0.5, 1 and 2.5 g/kg induced a 2.7-, 4.9- and 3.4-fold increase in Met-enk release from the NAcc. However, ethanol responses followed different kinetics, with earliest effects observed with the highest ethanol dose. In comparison, a 2.5-fold increase in peptide release was produced by 100 mM KCI. Ethanol, at a dose of 2.5 g/kg, induced a significant 66.7% decrease in Met-enk content in the NAcc, as well as a 76.4% reduction in peptide levels in the CP. Lower ethanol doses did not alter Met-enk content in these regions. On the other hand, an ethanol dose of 0.5 g/kg produced a non-significant decrease in Met-enk levels in the PFC. Our results suggest that ethanol-induced changes in enkephalin expression and release in regions of the mesocorticolimbic and nigrostriatal pathways could be involved in ethanol central effects. Released enkephalins by ethanol may modulate the doparninergic activity of mesolimbic neurons and play a critical role in ethanol reinforcement mechanisms.es_ES
dc.subject.kwEtanoles_ES
dc.subject.kwPéptidos opioideses_ES
dc.subject.kwMetionina-encefalinaes_ES
dc.subject.kwSistema dopaminérgico mesocorticolímbicoes_ES
dc.subject.kwReforzamientoes_ES
dc.subject.kwLiberaciónes_ES
dc.subject.koEthanoles_ES
dc.subject.koOpioid peptideses_ES
dc.subject.koMethionine–enkephalines_ES
dc.subject.koDopaminergic mesocorticolimbic systemes_ES
dc.subject.koReinforcementes_ES
dc.subject.koReleasees_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem