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Dopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortex

dc.creatorLópez-Ávila, A.
dc.creatorCoffeen, U.
dc.creatorOrtega-Legaspi, J.M.
dc.creatorDel Ángel, R.
dc.creatorPellicer, F.
dc.date.accessioned2017-06-30T03:54:37Z
dc.date.available2017-06-30T03:54:37Z
dc.date.issued2004es_ES
dc.identifier2368es_ES
dc.identifier.issn0304-3959es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7013
dc.identifier.urihttp://doi.org/10.1016/j.pain.2004.06.010es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSes_ES
dc.relation111 (1-2) 136-143 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleDopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortexes_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiat, Subdirecc Invest Neurociencias, Lab Neurofisiol Integrat, Ramon Fuente,Camino Xochimilco,101 San Lorenzo Hu, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailpellicer@imp.edu.mxes_ES
dc.relation.jnabreviadoPAINes_ES
dc.relation.journalPaines_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-6623es_ES
dc.identifier.doi10.1016/j.pain.2004.06.010es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaThe anterior cingulate cortex (ACC) plays a key role in pain processing. It has been reported that increased activity of glutamatergic projections into the ACC intensifies nociception| whereas dopaminergic projections inhibit it. The aim of this study was to evaluate the role of dopaminergic and NMDA systems of the ACC in the modulation of long-term nociception elicited by sciatic denervation in the rat. Score, onset and incidence of long-term nociception were measured by the autotomy behavior. The effects of a single microinjection into the ACC of different doses of dopamine (100 nM, 100 muM and 100 mM), a NMDA receptor antagonist (MK801 200 nM and 9.34 mM) and amantadine, a dopamine agonist and NMDA receptor antagonist (10, 100 and 1000 muM) were tested on long-term nociception. Dopamine diminished autotomy behavior in an inverse dose-dependent manner, with dopamine 100 nM as most effective concentration. MK801 and amantadine elicited a significant reduction on autotomy score. Prior injections of D1 and D2 receptor antagonists blocked the antinociceptive effects of amantadine on long-term nociceptive behavior. The present study suggests an interaction between dopaminergic and glutamatergic systems within the ACC in the genesis and maintenance of long-term nociception. (C) 2004 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.es_ES
dc.subject.kwDopaminaes_ES
dc.subject.kwRataes_ES
dc.subject.kwCingulada anterior cortezaes_ES
dc.subject.koDopaminees_ES
dc.subject.koRates_ES
dc.subject.koAnterior cingulate cortexes_ES


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