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dc.creatorMurray, Christopher J.L.
dc.creatorVos, Theo
dc.creatorLozano, Rafael
dc.creatorNaghavi, Mohsen
dc.creatorFlaxman, Abraham D.
dc.creatorMichaud, Catherine
dc.creatorEzzati, Majid
dc.creatorShibuya, Kenji
dc.creatorSalomón, Joshua A.
dc.creatorAbdalla, Safa
dc.creatorAboyans, Víctor
dc.creatorMarcenes, Wagner
dc.creatorJasrasaria, Rashmi
dc.creatorBlore, Jed D.
dc.creatorJayaraman, Sudha
dc.creatorJohns, Nicole
dc.creatorRichardson, Kathryn
dc.creatorJonas, Jost B.
dc.creatorShivakoti, Rupak
dc.creatorNarayan, K.M. Venkat
dc.creatorConnor, Myles D.
dc.creatorFlaxman, Seth
dc.creatorMori, Rintaro
dc.creatorKarthikeyan, Ganesan
dc.creatorPorrini, Esteban
dc.creatorCarmona, Loreto
dc.creatorKassebaum, Nicholas
dc.creatorPatten, Scott B.
dc.creatorHoy, Damian
dc.creatorAbraham, Jerry
dc.creatorAnderson, H. Ross
dc.creatorKawakami, Norito
dc.creatorCourville de Vaccaro, Karen
dc.creatorPourmalek, Farshad
dc.creatorKeren, Andre
dc.creatorKhoo, Jon-Paul
dc.creatorMedina-Mora, María Elena
dc.creatorSingh, David
dc.creatorMarch, Lyn
dc.creatorNelson, Paul K.
dc.creatorKing, Charles H.
dc.creatorKnowlton, Lisa Marie
dc.creatorPope, C. Arden
dc.creatorShepard, Donald S.
dc.creatorKobusingye, Olive
dc.creatorRanganathan, Dharani
dc.creatorBlyth, Fiona
dc.creatorCella, Claudia
dc.creatorKoranteng, Adolfo
dc.creatorBaxter, Amanda
dc.creatorMeltzer, Michele
dc.creatorBhandari, Bishal
dc.creatorKrishnamurthi, Rita
dc.creatorSingh, Gitanjali M.
dc.creatorCouser, William
dc.creatorLaden, Francine
dc.creatorBoussinesq, Michel
dc.creatorChou, David
dc.creatorLalloo, Ratilal
dc.creatorHaro, Josep Maria
dc.creatorAnderson, Laurie M.
dc.creatorLiu, Wei
dc.creatorLaslett, Laura L.
dc.creatorNelson, Robert G.
dc.creatorVan der Werf, Marieke J.
dc.creatorCowie, Benjamín C.
dc.creatorMensah, George A.
dc.creatorPrince, Martín
dc.creatorMerriman, Tony R.
dc.creatorWhiteford, Harvey
dc.creatorRivara, Frederick P.
dc.creatorMeyer, Ana-Claire
dc.creatorLim, Stephen S.
dc.creatorTowbin, Jeff Rey A.
dc.creatorMiglioli, Valeria
dc.creatorScott, James Graham
dc.creatorMcDermott, Mary M.
dc.creatorChen, Honglei L.
dc.creatorDorsey, E. Ray
dc.creatorMiller, Matthew
dc.creatorMiller, Ted R.
dc.creatorFelson, David T.
dc.creatorNevitt, Michael C.
dc.creatorRoberts, Thomas
dc.creatorBahalim, Adil N.
dc.creatorMitchell, Philip B.
dc.creatorVan Os, Jim
dc.creatorCriqui, Michael H.
dc.creatorFowkes, Francis Gerry R.
dc.creatorMock, Charles
dc.creatorColson, K. Ellicott
dc.creatorElbaz, Alexis
dc.creatorMocumbi, Ana Olga
dc.creatorPérez Padilla, Rogelio
dc.creatorLeasher, Janet L.
dc.creatorMoffitt, Terrie E.
dc.creatorMarks, Guy B.
dc.creatorCheng, A. Tai-Ann
dc.creatorMurdoch, Michele E.
dc.creatorMokdad, Ali A.
dc.creatorPullan, Rachel L.
dc.creatorBarrero, Lope H.
dc.creatorFransen, Marlene
dc.creatorNewton, Charles R.
dc.creatorNolte, Sandra
dc.creatorWiebe, Natasha
dc.creatorNorman, Paul
dc.creatorBolliger, Ian
dc.creatorSleet, David A.
dc.creatorIbeanusi, Sydney E.
dc.creatorBennett, Derrick
dc.creatorNorman, Rosana
dc.creatorWang, Mengru R.
dc.creatorAli, Mohammed K.
dc.creatorO'Donnell, Martín
dc.creatorThomson, W. Murray
dc.creatorNair, M. Nathan
dc.creatorDherani, Mukesh
dc.creatorEbel, Beth
dc.creatorO'Hanlon, Simón
dc.creatorWang, Wenzhi Z.
dc.creatorOlives, Casey
dc.creatorOmer, Saad B.
dc.creatorRobinson, Carolyn
dc.creatorBonaventure, Audrey
dc.creatorRamaiah, Kapa D.
dc.creatorSliwa, Karen
dc.creatorOrtblad, Katrina
dc.creatorOsborne, Richard
dc.creatorVavilala, Mónica S.
dc.creatorBartels, David H.
dc.creatorBikbov, Boris
dc.creatorFreeman, Michael K.
dc.creatorHarrison, James E.
dc.creatorOzgediz, Doruk
dc.creatorFeigin, Valery
dc.creatorRodríguez De León, Felipe
dc.creatorFinucane, Mariel M.
dc.creatorPage, Andrew
dc.creatorBoufous, Soufi Ane
dc.creatorPahari, Bishnu
dc.creatorGanatra, Hammad A.
dc.creatorHill, Catherine
dc.creatorPandian, Jeyaraj Durai
dc.creatorMontico, Marcella
dc.creatorEdmond, Karen
dc.creatorPión, Sebastien
dc.creatorPanozo Rivero, Andrea
dc.creatorSmith, Emma
dc.creatorCoffeng, Luc E.
dc.creatorRonfani, Luca
dc.creatorWatt, Kerianne
dc.creatorRoom, Robín
dc.creatorCross, Marita
dc.creatorWiersma, Steven T.
dc.creatorRosenfeld, Lisa C.
dc.creatorBasáñez, María-Gloria
dc.creatorCharlson, Fiona
dc.creatorRushton, Lesley
dc.creatorBirbeck, Gretchen
dc.creatorHay, Roderick J.
dc.creatorLeigh, James
dc.creatorSacco, Ralph L.
dc.creatorBenjamín, Emelia J.
dc.creatorMacIntyre, Michael F.
dc.creatorSmith, Jennifer L.
dc.creatorWilkinson, James D.
dc.creatorErskine, Holly
dc.creatorSaha, Sukanta
dc.creatorColan, Steven D.
dc.creatorMarks, Robín
dc.creatorSampson, Uchechukwu
dc.creatorHuang, John J.
dc.creatorLipnick, Michael
dc.creatorSánchez-Riera, Lidia
dc.creatorTleyjeh, Imad M.
dc.creatorPearce, Neil
dc.creatorSanman, Ella
dc.creatorRazavi, Homie
dc.creatorHigashi, Hideki
dc.creatorSchwebel, David C.
dc.creatorWeatherall, David J.
dc.creatorEspíndola, Patricia
dc.creatorMatsumori, Akira
dc.creatorStapelberg, Nicolas J.C.
dc.creatorBernabe, Eduardo
dc.creatorDabhadkar, Kaustubh C.
dc.creatorSteer, Andrew
dc.creatorGabbe, Belinda J.
dc.creatorBraithwaite, Tasanee
dc.creatorFerri, Cleusa P.
dc.creatorSteiner, Timothy
dc.creatorCondon, John
dc.creatorDriscoll, Tim
dc.creatorStolk, Wilma A.
dc.creatorCarabin, Helene
dc.creatorSingh, Jasvinder A.
dc.creatorLathlean, Tim
dc.creatorLimb, Elizabeth
dc.creatorStovner, Lars Jacob
dc.creatorSudfeld, Christopher
dc.creatorSyed, Sana
dc.creatorWilliams, Hywel C.
dc.creatorGabriel, Sherine E.
dc.creatorWeinstock, Martín A.
dc.creatorBrayne, Carol
dc.creatorTamburlini, Giorgio
dc.creatorTavakkoli, Mohammad
dc.creatorColquhoun, Samantha
dc.creatorEwoigbokhan, Stalin E.
dc.creatorMatzopoulos, Richard
dc.creatorMoradi-Lakeh, Maziar
dc.creatorTaylor, Hugh R.
dc.creatorMabweijano, Jacqueline
dc.creatorWilliams, Sean R.M.
dc.creatorAtkinson, Charles
dc.creatorTaylor, Jennifer A.
dc.creatorAggarwal, Rakesh
dc.creatorBhalla, Kavi
dc.creatorBaddour, Larry M.
dc.creatorTaylor, William J.
dc.creatorSegui-Gómez, María
dc.creatorLin, John Kent
dc.creatorUndurraga, Eduardo A.
dc.creatorThomas, Bernadette
dc.creatorBridgett, Lisa
dc.creatorHoffman, Howard
dc.creatorBin Abdulhak, Aref
dc.creatorCooper, Leslie T.
dc.creatorWitt, Emma
dc.creatorDahiya, Manu
dc.creatorWolfe, Frederick
dc.creatorFarzadfar, Farshad
dc.creatorHavmoeller, Rasmus
dc.creatorWoolf, Anthony D.
dc.creatorForeman, Kyle
dc.creatorMorawska, Lidia
dc.creatorPérez-Ruíz, Fernando
dc.creatorWulf, Sarah
dc.creatorFerrari, Alize
dc.creatorBrooker, Simón
dc.creatorDahodwala, Nabila
dc.creatorLipshultz, Steven E.
dc.creatorYeh, Pon-Hsiu
dc.creatorHotez, Peter J.
dc.creatorRegan, Mathilda
dc.creatorZaidi, Anita K.M.
dc.creatorNaldi, Luigi
dc.creatorPhillips, Michael R.
dc.creatorZheng, Zhi-Jie
dc.creatorThurston, George D.
dc.creatorZonies, David
dc.creatorWeintraub, Robert
dc.creatorBarker-Collo, Suzanne
dc.creatorLópez, Alan D.
dc.creatorCorriere, Matthew
dc.creatorLoane, María
dc.creatorRehm, Juergen T.
dc.creatorBrooks, Peter
dc.creatorFevre, Eric M.
dc.creatorBrugha, Traolach S.
dc.creatorMayosi, Bongani M.
dc.creatorGarcía, Bianca
dc.creatorMallinger, Leslie
dc.creatorBryan-Hancock, Claire
dc.creatorAlvarado, Miriam
dc.creatorLevinson, Daphna
dc.creatorBucello, Chiara
dc.creatorHaring, Diana
dc.creatorBourne, Rupert
dc.creatorPesudovs, Konrad
dc.creatorBuchbinder, Rachelle
dc.creatorBuckle, Geoffrey
dc.creatorBudke, Christine M.
dc.creatorDamsere-Derry, James
dc.creatorMcAnulty, John H.
dc.creatorCortinovis, Mónica
dc.creatorGaspari, Flavio
dc.creatorBurch, Michael
dc.creatorBurney, Peter
dc.creatorOhno, Summer Lockett
dc.creatorRein, David B.
dc.creatorShahraz, Saeid
dc.creatorBurstein, Roy
dc.creatorPopova, Svetlana
dc.creatorDanaei, Goodarz
dc.creatorAli, Suad Eltahir
dc.creatorCalabria, Bianca
dc.creatorDolk, Helen
dc.creatorAckerman, Ilana
dc.creatorCampbell, Benjamín
dc.creatorBlack, James A.
dc.creatorPhillips, David
dc.creatorChugh, Sumeet S.
dc.creatorCanter, Charles E.
dc.creatorGillum, Richard F.
dc.creatorMwaniki, Michael K.
dc.creatorFlood, Louise
dc.creatorJacobsen, Kathryn H.
dc.creatorDavis, Adrián
dc.creatorDe Leo, Diego
dc.creatorLyons, Ronan
dc.creatorMoran, Andrew
dc.creatorDegenhardt, Louisa
dc.creatorMargolis, David J.
dc.creatorShin, Hwashin
dc.creatorTonelli, Marcello
dc.creatorDellavalle, Robert
dc.creatorMalekzadeh, Reza
dc.creatorGmel, Gerhard
dc.creatorPierce, Kelsey
dc.creatorDelossantos, Allyne
dc.creatorNaidoo, Kovin
dc.creatorWeisskopf, Marc G.
dc.creatorDenenberg, Julie
dc.creatorSingleton, Jessica
dc.creatorUbeda, Clotilde
dc.creatorDerrett, Sarah
dc.creatorCarapetis, Jonathan
dc.creatorDes Jarlais, Don C.
dc.creatorErwin, Patricia J.
dc.creatorDharmaratne, Samath D.
dc.creatorJames, Spencer L.
dc.creatorPolanczyk, Guilherme V.
dc.creatorWeissman, Myrna M.
dc.creatorGonzález-Medina, Diego
dc.creatorManivannan, Sivabalan
dc.creatorGosselin, Richard
dc.creatorRemuzzi, Guiseppe
dc.creatorMcGill, Neil
dc.creatorGrainger, Rebecca
dc.creatorDuber, Herbert
dc.creatorPerico, Norberto
dc.creatorGrant, Bridget
dc.creatorMonasta, Lorenzo
dc.creatorGakidou, Emmanuela
dc.creatorTruelsen, Thomas
dc.creatorAhn, Stephanie Y.
dc.creatorGroeger, Justina
dc.creatorGuillemin, Francis
dc.creatorBell, Michelle L.
dc.creatorJarvis, Deborah
dc.creatorMcGrath, John
dc.creatorGunnell, David
dc.creatorGupta, Ramyani
dc.creatorPolinder, Suzanne
dc.creatorWhite, Richard A.
dc.creatorBlencowe, Hannah
dc.creatorHaagsma, Juanita
dc.creatorVenketasubramanian, N.
dc.creatorAndrews, Kathryn G.
dc.creatorHagan, Holly
dc.creatorLee, Yong Yi
dc.creatorDíaz-Torne, César
dc.creatorHalasa, Yara A.
dc.creatorForouzanfar, Mohammad H.
dc.creatorTsilimbaris, Miltiadis K.
dc.creatorHoen, Bruno
dc.creatorHall, Wayne
dc.date.accessioned2017-06-30T03:54:30Z
dc.date.available2017-06-30T03:54:30Z
dc.date.issued2012
dc.identifier2366es_ES
dc.identifier.issn0140-6736es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/7011
dc.language.isoenges_ES
dc.publisherElsevier Science INC, 360 Park Ave South, New York, NY 10010-1710 USAes_ES
dc.relation380 (9859) 2197-2223 p.es_ES
dc.relationversión del editores_ES
dc.rightsAcceso Cerradoes_ES
dc.subjectMEDICINA Y CIENCIAS DE LA SALUDes_ES
dc.subject.meshPublic health - Utilityes_ES
dc.subject.meshRisk factorses_ES
dc.subject.meshEconomic costes_ES
dc.subject.meshMortalityes_ES
dc.subject.meshPopulationes_ES
dc.subject.meshAustraliaes_ES
dc.subject.meshCountrieses_ES
dc.subject.meshDeathes_ES
dc.subject.meshLostes_ES
dc.subject.meshMeta-analisyses_ES
dc.titleDisability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010es_ES
dc.typeArticlees_ES
dc.contributor.affiliationUniv Washington, Inst Hlth Metr & Evaluat, 2301 5th Ave,Suite 600, Seattle, WA 98121 USA.es_ES
dc.contributor.emailcjlm@uw.edues_ES
dc.relation.jnabreviadoLANCETes_ES
dc.relation.journalLancetes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1474-547Xes_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaBackground Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate disease burden worldwide and for 21 regions for 1990, 2005, and 2010 with methods to enable meaningful comparisons over time. Methods We calculated DALYs as the sum of years of life lost (YLLs) and years lived with disability (YLDs). DALYs were calculated for 291 causes, 20 age groups, both sexes, and for 187 countries, and aggregated to regional and global estimates of disease burden for three points in time with strictly comparable definitions and methods. YLLs were calculated from age-sex-country-time-specific estimates of mortality by cause, with death by standardised lost life expectancy at each age. YLDs were calculated as prevalence of 1160 disabling sequelae, by age, sex, and cause, and weighted by new disability weights for each health state. Neither YLLs nor YLDs were age-weighted or discounted. Uncertainty around cause-specific DALYs was calculated incorporating uncertainty in levels of all-cause mortality, cause-specific mortality, prevalence, and disability weights. Findings Global DALYs remained stable from 1990 (2.503 billion) to 2010 (2.490 billion). Crude DALYs per 1000 decreased by 23% (472 per 1000 to 361 per 1000). An important shift has occurred in DALY composition with the contribution of deaths and disability among children (younger than 5 years of age) declining from 41% of global DALYs in 1990 to 25% in 2010. YLLs typically account for about half of disease burden in more developed regions (high-income Asia Pacific, western Europe, high-income North America, and Australasia), rising to over 80% of DALYs in sub-Saharan Africa. In 1990, 47% of DALYs worldwide were from communicable, maternal, neonatal, and nutritional disorders, 43% from non-communicable diseases, and 10% from injuries. By 2010, this had shifted to 35%, 54%, and 11%, respectively. Ischaemic heart disease was the leading cause of DALYs worldwide in 2010 (up from fourth rank in 1990, increasing by 29%), followed by lower respiratory infections (top rank in 1990| 44% decline in DALYs), stroke (fifth in 1990| 19% increase), diarrhoeal diseases (second in 1990| 51% decrease), and HIV/AIDS (33rd in 1990| 351% increase). Major depressive disorder increased from 15th to 11th rank (37% increase) and road injury from 12th to 10th rank (34% increase). Substantial heterogeneity exists in rankings of leading causes of disease burden among regions. Interpretation Global disease burden has continued to shift away from communicable to non-communicable diseases and from premature death to years lived with disability. In sub-Saharan Africa, however, many communicable, maternal, neonatal, and nutritional disorders remain the dominant causes of disease burden. The rising burden from mental and behavioural disorders, musculoskeletal disorders, and diabetes will impose new challenges on health systems. Regional heterogeneity highlights the importance of understanding local burden of disease and setting goals and targets for the post-2015 agenda taking such patterns into account. Because of improved definitions, methods, and data, these results for 1990 and 2010 supersede all previously published Global Burden of Disease results.es_ES
dc.subject.kwEnfermedades y lesioneses_ES
dc.subject.kwAnálisis sistemáticoes_ES
dc.subject.koDisability-adjustedes_ES
dc.subject.koSystematic analysises_ES


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