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Cellular and biochemical actions of melatonin which protect against free radicals: Role in neurodegenerative disorders

dc.creatorOrtiz, Genaro G.
dc.creatorBenitez-King, Gloria A.
dc.creatorRosales-Corral, Sergio A.
dc.creatorPacheco-Moises, Fermin P.
dc.creatorVelazquez-Brizuela, Irma E.
dc.date.accessioned2017-06-30T03:52:21Z
dc.date.available2017-06-30T03:52:21Z
dc.date.issued2008es_ES
dc.identifier2342es_ES
dc.identifier.issn1570-159Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6987
dc.identifier.urihttp://doi.org/10.2174/157015908785777201es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687933/es_ES
dc.language.isoenges_ES
dc.relation6 (3) 203-214 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCellular and biochemical actions of melatonin which protect against free radicals: Role in neurodegenerative disorderses_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria, Lab Neurofarmacol, Mexico City, DF, Mexicoes_ES
dc.contributor.emailgenarogabriel@yahoo.comes_ES
dc.relation.jnabreviadoCURR NEUROPHARMACOLes_ES
dc.relation.journalCurrent Neuropharmacologyes_ES
dc.date.published2008es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.2174/157015908785777201es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaMolecular oxygen is toxic for anaerobic organisms but it is also obvious that oxygen is poisonous to aerobic organisms as well, since oxygen plays an essential role for inducing molecular damage. Molecular oxygen is a triplet radical in its ground-stage (.O-O.) and has two unpaired electrons that can undergoes consecutive reductions of one electron and generates other more reactive forms of oxygen known as free radicals and reactive oxygen species. These reactants (including superoxide radicals, hydroxyl radicals) possess variable degrees of toxicity. Nitric oxide (NO.) contains one unpaired electron and is, therefore, a radical. NO. is generated in biological tissues by specific nitric oxide synthases and acts as an important biological signal. Excessive nitric oxide production, under pathological conditions, leads to detrimental effects of this molecule on tissues, which can be attributed to its diffusion-limited reaction with superoxide to form the powerful and toxic oxidant, peroxynitrite. Reactive oxygen and nitrogen species are molecular "renegades"; these highly unstable products tend to react rapidly with adjacent molecules, donating, abstracting, or even sharing their outer orbital electron(s). This reaction not only changes the target molecule, but often passes the unpaired electron along to the target, generating a second free radical, which can then go on to react with a new target amplifying their effects. This review describes the mechanisms of oxidative damage and its relationship with the most highly studied neurodegenerative diseases and the roles of melatonin as free radical scavenger and neurocytoskeletal protector.es_ES
dc.subject.kwMelatoninaes_ES
dc.subject.kwAlzheimeres_ES
dc.subject.kwParkinsones_ES
dc.subject.kwEstrés oxidativoes_ES
dc.subject.kwNOes_ES
dc.subject.kwNeurodegeneraciónes_ES
dc.subject.koMelatonines_ES
dc.subject.koAlzheimeres_ES
dc.subject.koParkinsones_ES
dc.subject.koOxidative stresses_ES
dc.subject.koNOes_ES
dc.subject.koNeurodegenerationes_ES


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