Mostrar el registro sencillo del ítem

Blockade of the anxiolytic-like action of ipsapirone and buspirone, but not that of 8-OH-DPAT, by adrenalectomy in male rats

dc.creatorLópez-Rubalcava, C.
dc.creatorCruz, S.L.
dc.creatorFernández-Guasti, A.
dc.date.accessioned2017-06-30T03:52:12Z
dc.date.available2017-06-30T03:52:12Z
dc.date.issued1999es_ES
dc.identifier2340es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6985
dc.identifier.urihttps://doi.org/10.1016/S0306-4530(98)00090-0es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation24, 409-422 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBlockade of the anxiolytic-like action of ipsapirone and buspirone, but not that of 8-OH-DPAT, by adrenalectomy in male ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Farmacologıa y Toxicologıa, Seccion de Terapeutica Experimental, CINVESTAV,PO Box 22026, 14000 Mexico D.F., Mexicoes_ES
dc.contributor.emailclopez@buzon.main.conacyt.mxes_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeOxfordes_ES
dc.date.published1999es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/S0306-4530(98)00090-0es_ES
dc.description.abstractotrodiomaThe effect of the 5-HT1A agonists ipsapirone (5 mg/kg), buspirone (5 mg/kg) and 8-OH-DPAT (0.5 mg/kg) on experimental anxiety was examined in sham-operated, adrenalectomized and adrenally demedullated male rats. The animal model of anxiety used was the defensive burying test. At the doses selected, all 5-HT1A compounds produced an anxiolytic-like action by reducing the burying behavior in both sham-operated and demedullated rats. However, in adrenalectomized subjects, while 8-OH-DPAT still reduced burying behavior, ipsapirone and buspirone lost their action. Data suggest that adrenocortical secretions play a role in the anxiolytic-like actions of buspirone and ipsapirone, but not in those of 8-OH-DPAT. Buspirone and ipsapirone also produced a reduction in burying behavior latency in sham-operated animals that was not observed in adrenalectomized or adrenally demedullated rats. These data suggest that adrenaline may be participating in the action of these compounds on the burying behavior latency. Present findings support possible direct relationships between the stimulation of 5-HT1A receptors and adrenal secretions.es_ES
dc.subject.kwBuspironaes_ES
dc.subject.kwIpsapironaes_ES
dc.subject.kw8-OH-DPATes_ES
dc.subject.kwSuprarrenalectomíaes_ES
dc.subject.kwDemedullationes_ES
dc.subject.kwAnsiedades_ES
dc.subject.koBuspironees_ES
dc.subject.koIpsapironees_ES
dc.subject.ko8-OH-DPATes_ES
dc.subject.koAdrenalectomyes_ES
dc.subject.koDemedullationes_ES
dc.subject.koAnxietyes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem