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Blockade of corticosteroid receptors induces anxiolytic-like effects in streptozotocin-induced diabetic mice, and synergizes with diazepam

dc.creatorLópez-Rubalcava, Carolina
dc.creatorPaéz-Martínez, Nayeli
dc.creatorOikawa, Julian
dc.date.accessioned2017-06-30T03:52:08Z
dc.date.available2017-06-30T03:52:08Z
dc.date.issued2013es_ES
dc.identifier2339es_ES
dc.identifier.issn0955-8810es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6984
dc.identifier.urihttp://doi.org/10.1097/FBP.0b013e3283637de2es_ES
dc.language.isoenges_ES
dc.publisherLIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USAes_ES
dc.relation24 (4) 320-327 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleBlockade of corticosteroid receptors induces anxiolytic-like effects in streptozotocin-induced diabetic mice, and synergizes with diazepames_ES
dc.typearticlees_ES
dc.contributor.affiliationCinvestav Sede Sur, Dept Pharmacobiol, Sede Sur Calzada Tenorios 235, Mexico City 14330, DF, Mexico.es_ES
dc.contributor.emailclopezr@cinvestav.mxes_ES
dc.relation.jnabreviadoBEHAV PHARMACOLes_ES
dc.relation.journalBehavioural pharmacologyes_ES
dc.identifier.placeFiladelfiaes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1473-5849es_ES
dc.identifier.doi10.1097/FBP.0b013e3283637de2es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaAnxiety disorder is a psychiatric condition reported in diabetic patients. It is known that hypothalamus-pituitary-adrenal axis activity is increased in these patients and corticosteroids levels are augmented, whereas the anxiolytic actions of diazepam are reduced. The aim of this study was to evaluate the participation of glucocorticoid (GR) and mineralocorticoid (MR) receptors in anxiety in diabetic mice and whether the blockade of these receptors synergizes with diazepam in the diabetic condition, leading to a reduction of anxiety. Diabetes was induced with streptozotocin (STZ) and anxiety-like levels were evaluated on days 5, 15, and 30 after STZ. Independent groups of control and diabetic mice were treated with diazepam (0.25-2.0 mg/kg), RU-486 (12.5-100 mg/kg), spironolactone (12.5-100 mg/kg), or the combination of suboptimal doses of diazepam and MR or GR antagonists. Results showed that STZ increased anxiety-like behavior 15 days after its administration. The response to diazepam was reduced in diabetic mice, whereas GR and MR blockade induced anxiolytic-like effects in these animals. Coadministration of MR or GR antagonists synergized with diazepam to induce anxiolytic-like effects. The results suggest the participation of corticosteroid receptors in the increased anxiety-like response in diabetic mice and that the blockade of these receptors facilitates the effects of diazepam.es_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwComportamiento de enterramientoes_ES
dc.subject.kwCorticoideses_ES
dc.subject.kwDiabeteses_ES
dc.subject.kwReceptores de glucocorticoideses_ES
dc.subject.kwReceptores de mineralocorticoideses_ES
dc.subject.kwDiazepames_ES
dc.subject.kwMousees_ES
dc.subject.koAnxietyes_ES
dc.subject.koBurying behaviores_ES
dc.subject.koCorticosteroidses_ES
dc.subject.koDiabeteses_ES
dc.subject.koGlucocorticoid receptorses_ES
dc.subject.koMineralocorticoid receptorses_ES
dc.subject.koDiazepames_ES
dc.subject.koRatónes_ES


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