Mostrar el registro sencillo del ítem

Association study between BDNF gene variants and Mexican patients with obsessive-compulsive disorder

dc.creatorMárquez, Lidia
dc.creatorCamarena, Beatriz
dc.creatorHernández, Sandra
dc.creatorLóyzaga, Cristina
dc.creatorVargas, Luis
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-30T03:51:35Z
dc.date.available2017-06-30T03:51:35Z
dc.date.issued2013es_ES
dc.identifier2331es_ES
dc.identifier.issn0924-977Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6976
dc.identifier.urihttps://doi.org/10.1016/j.euroneuro.2013.08.001es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSes_ES
dc.relation23 (11) 1600-1605 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAssociation study between BDNF gene variants and Mexican patients with obsessive-compulsive disorderes_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria Ramon Fuente Muniz, Dept Genet, Calz Mexico Xochimilco 101 Col San Lorenzo, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailcamare@imp.edu.mxes_ES
dc.relation.jnabreviadoEUR NEUROPSYCHOPHARMACOLes_ES
dc.relation.journalEuropean neuropsychopharmacologyes_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-7862es_ES
dc.identifier.doi10.1016/j.euroneuro.2013.08.001es_ES
dc.description.monthNoves_ES
dc.description.abstractotrodiomaObsessive-compulsive disorder (OCD) is a psychiatric disorder whose etiology is not yet known. We investigate the role of three variants of the BDNF gene (rs6265, rs1519480 and rs7124442) by single SNP and haplotype analysis in OCD Mexican patients using a case-control and family-based association design. BDNF gene variants were genotyped in 283 control subjects, 232 OCD patients and first degree relatives of 111 OCD subjects. Single SNP analysis in case-control study showed an association between rs6265 and OCD with a high frequency of Val/Val genotype and Val allele (p=0.0001 and p=0.0001, respectively). Also, genotype and allele analysis of rs1519480 showed significant differences (p=0.0001, p=0.0001| respectively) between OCD and control groups. Haplotype analysis showed a high frequency of A-T (rs6265-rs1519480) in OCD patients compared with the control group (OR=2.06 [1.18-3.59], p=0.0093) and a low frequency of haplotype A-C in the OCD patients (OR=0.04 [0.01-0.16], p=0.000002). The family-based association study showed no significant differences in the transmission of any variant. Our study replicated the association between BDNF Val66Met gene polymorphism and OCD. Also, we found a significant association of rs1519480 in OCD patients compared with a control group, region that has never been analyzed in OCD. In conclusion, our findings suggest that BDNF gene could be related to the development of OCD. (C) 2013 Elsevier B.V. and ECNP. All rights reserved.es_ES
dc.subject.kwTOCes_ES
dc.subject.kwBDNFes_ES
dc.subject.kwEstudio de la Asociaciónes_ES
dc.subject.kwHaplotiposes_ES
dc.subject.koOCDes_ES
dc.subject.koBDNFes_ES
dc.subject.koAssociation studyes_ES
dc.subject.koHaplotypeses_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem