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Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population

dc.creatorMontano Loza, Aldo J.
dc.creatorRamírez Iglesias, María Teresa
dc.creatorPérez Diaz, Iván
dc.creatorCruz Castellanos, Socorro Cruz
dc.creatorGarcía Andrade, Consuelo
dc.creatorMedina Mora, María Elena
dc.creatorRobles Díaz, Guillermo
dc.creatorKershenobich, David
dc.creatorGutiérrez Reyes, Gabriela
dc.date.accessioned2017-06-30T03:51:30Z
dc.date.available2017-06-30T03:51:30Z
dc.date.issued2006es_ES
dc.identifier2330es_ES
dc.identifier.issn0741-8329es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6975
dc.identifier.urihttps://doi.org/10.1016/j.alcohol.2006.07.001es_ES
dc.language.isoenges_ES
dc.publisherElsevier Science INC, 360 Park Ave South, New York, NY 10010-1710 USAes_ES
dc.relation39 (2) 73-79 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshAdultes_ES
dc.subject.meshAgedes_ES
dc.subject.meshAged, 80 and overes_ES
dc.subject.meshAlcohol dehydrogenase-Geneticses_ES
dc.subject.meshAlcoholism-Geneticses_ES
dc.subject.meshAlcoholism-Metabolismes_ES
dc.subject.meshAldehyde dehydrogenase-Geneticses_ES
dc.subject.meshCytochrome P-450 CYP2E1-Geneticses_ES
dc.subject.meshDeoxyribonucleases, type II site-specific-Metabolismes_ES
dc.subject.meshEthanol-Metabolismes_ES
dc.subject.meshFemalees_ES
dc.subject.meshGene frequencyes_ES
dc.subject.meshGenotypees_ES
dc.subject.meshHumanses_ES
dc.subject.meshIndians, North American-Geneticses_ES
dc.subject.meshMalees_ES
dc.subject.meshMexicoes_ES
dc.subject.meshMiddle agedes_ES
dc.subject.meshPolymorphism, restriction fragment lengthes_ES
dc.titleAssociation of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) populationes_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Ciencias Med & Nutr, Dept Gastroenterol, Vasco Quiroga 15,Secc 26, Mexico City 14000, DF, Mexico.es_ES
dc.contributor.emailmontanoa@quetzal.innsz.mxes_ES
dc.relation.jnabreviadoALCOHOLes_ES
dc.relation.journalAlcoholes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1873-6823es_ES
dc.identifier.doi10.1016/j.alcohol.2006.07.001es_ES
dc.description.monthJunes_ES
dc.description.abstractotrodiomaAssociation studies provide a powerful approach to link DNA variants and genetic predisposition to complex diseases. In this study, we determined the genotype and allelic frequencies of genes encoding enzymes involved in alcohol metabolism in alcoholic and nonalcoholic subjects of related ethnicity. A total of 118 individuals of Otomi Mexican Indian ancestry were included. Fifty-nine were chronic alcoholics according to WHO criteria and alcohol dependents according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM IV) criteria. They were compared to 59 teetotalers or alcohol consumers of < 10 g per day. The restriction fragment length polymorphisms analyzed were ADH1B/MaeIII, ALDH2/MboII, CYP2E1/DraI, CYP2E1/RsaI, and CYP2E1/TaqI. Of the studied polymorphisms, a significant difference between alcoholic and nonalcoholic Otomies was observed only in the CYP2E1/TaqI. The common genotype in alcoholics was A1/A2 (54%), and in nonalcoholics the homozygous A2/A2 (63%) (odds ratio [OR]: 0.28| 95% confidence interval [CI]: 0.13-0.60| P = .002). The frequency of the mutant allele A1 was significantly higher in alcoholics than in nonalcoholics (41 vs. 21%| OR: 2.4| 95% CI: 1.3-4.3| P = .003). This documents the presence of a polymorphism of CYP2E1 that is overexpressed in alcoholic Otomies, in which the variant allele (A1 of CYP2E1/TaqI) is associated with increased susceptibility to alcoholism. The appreciation that this finding may be an additional factor contributing to the high frequency of liver cirrhosis in Otomies requires further investigation.es_ES
dc.subject.kwAlcoholismoes_ES
dc.subject.kwPolimorfismoses_ES
dc.subject.kwAlcohol deshidrogenasaes_ES
dc.subject.kwAldehído deshidrogenasaes_ES
dc.subject.kwCYP2E1es_ES
dc.subject.koAlcoholismes_ES
dc.subject.koPolymorphismses_ES
dc.subject.koAlcohol dehydrogenasees_ES
dc.subject.koAldehyde dehydrogenasees_ES
dc.subject.koCYP2E1es_ES


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