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Anxiolytic-like and antinociceptive effects of 2(S)-neoponcirin in mice.

dc.creatorCassani, Julia
dc.creatorEscalona Araujo, Anna G.
dc.creatorMartínez-Vázquez, Mariano
dc.creatorManjarrez, Norberto
dc.creatorMoreno, Julia
dc.creatorEstrada-Reyes, Rosa
dc.date.accessioned2017-06-30T03:51:17Z
dc.date.available2017-06-30T03:51:17Z
dc.date.issued2013es_ES
dc.identifier2327es_ES
dc.identifier.issn1420-3049es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6972
dc.identifier.urihttps://doi.org/10.3390/molecules18077584es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269808/es_ES
dc.language.isoenges_ES
dc.publisherBasel, Switzerland : MDPIes_ES
dc.relation18 (7) 7584-7599 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytic-like and antinociceptive effects of 2(S)-neoponcirin in mice.es_ES
dc.typearticlees_ES
dc.contributor.affiliationDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco, Mexico D.F. C.P. 04960, Mexicoes_ES
dc.contributor.emailrestrada@imp.edu.mx | estrarosa@hotmail.comes_ES
dc.relation.jnabreviadoMOLECULESes_ES
dc.relation.journalMoleculeses_ES
dc.identifier.placeSuizaes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doi10.3390/molecules18077584es_ES
dc.description.abstractotrodiomaSTUDY AIMS: 2(S)-neopincirin (NEO) is a constituent from of Clinopodium mexicanum, which is used in traditional Mexican herbal medicine for its tranquilizing and analgesic properties. This study investigated the anxiolytic-like, sedative and antinociceptive effects of NEO in several mice models. MATERIAL AND METHODS: The anxiolytic-like effect was evaluated in the hole-board (HBT) and Open Field Tests (OFT)| sedative effect was evaluated in sleeping time induced by sodium pentobarbital, and its antinociceptive actions were measured in the hot plate test. To evaluate if the GABA receptor could be involved in the anxiolytic-like effect produced by NEO, in independent experiments, the effects produced by co-administration of NEO plus muscimol (MUS) and NEO plus Pitrotoxin (PTX) were evaluated in the HBT. RESULTS: NEO was isolated from Clinopodium mexicanum leaves. The NMR, MS and optic rotation data helped establish its identity as (2S)-5-hydroxy-4'-methoxyflavanone-7-O-{_-glucopyranosyl-(1_6)-_-rhamnoside}. NEO showed an anxiolytic-like effect and was able to counter the nociception induced by a thermal stimulus in a dose-dependent manner. PTX blocked the anxiolytic-like effect of NEO, while MUS was able to enhance it. CONCLUSIONS: The findings of present work demonstrated that NEO possesses anxiolytic-like and antinociceptive effects in mice. Such effects are not associated with changes in the locomotor activity. These results supported the notion that anxiolytic-like effect of NEO involves the participation of GABAergic system.es_ES
dc.subject.meshmAnalgesics-Pharmacologyes_ES
dc.subject.meshmAnimalses_ES
dc.subject.meshmAnti-Anxiety Agents-Pharmacologyes_ES
dc.subject.meshmBehavior, Animal-Drug Effectses_ES
dc.subject.meshmDrug Combinationses_ES
dc.subject.meshmFlavonoids-Pharmacologyes_ES
dc.subject.meshmGABA Agents-Pharmacologyes_ES
dc.subject.meshmGlycosides-Pharmacologyes_ES
dc.subject.meshmHerbal Medicinees_ES
dc.subject.meshmHypnotics and Sedatives-Pharmacologyes_ES
dc.subject.meshmLamiaceae-Metabolismes_ES
dc.subject.meshmMalees_ES
dc.subject.meshmMicees_ES
dc.subject.meshmMotor Activity-Drug effectses_ES
dc.subject.meshmMuscimol-Pharmacologyes_ES
dc.subject.meshmNociception-Drug effectses_ES
dc.subject.meshmPlant Extracts-Pharmacologyes_ES
dc.subject.meshmSleep-Drug effectses_ES
dc.subject.meshm2(S)-neoponcirines_ES
dc.subject.meshmAnalgesicses_ES
dc.subject.meshmAnti-Anxiety Agentses_ES
dc.subject.meshmDrug Combinationses_ES
dc.subject.meshmFlavonoidses_ES
dc.subject.meshmGABA Agentses_ES
dc.subject.meshmGlycosideses_ES
dc.subject.meshmHypnotics and Sedativeses_ES
dc.subject.meshmPlant Extractses_ES
dc.subject.meshmMuscimoles_ES
dc.subject.kwNeoponcirines_ES
dc.subject.kwComo Ansiolíticoses_ES
dc.subject.kwClinopodium Mexicanoes_ES
dc.subject.kwToronjil de montees_ES
dc.subject.kwAnalgésicoes_ES
dc.subject.kwSistema GABAérgicoes_ES
dc.subject.koNeoponcirines_ES
dc.subject.koAnxiolytic-likees_ES
dc.subject.koClinopodium mexicanumes_ES
dc.subject.koToronjil de montees_ES
dc.subject.koAnalgesices_ES
dc.subject.koGABAergic systemes_ES


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