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Anxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to mu-opioid receptor activation in rat nucleus accumbens

dc.creatorMorales-Mulia, M.
dc.creatorEstrada-Camarena, E.
dc.creatorAmaya, M.I.
dc.creatorMejía-Mauries, S.
dc.creatorSollozo-Dupont, I.
dc.creatorMengod, G.
dc.creatorDe Gortari, P.
dc.date.accessioned2017-06-30T03:51:12Z
dc.date.available2017-06-30T03:51:12Z
dc.date.issued2012es_ES
dc.identifier2326es_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6971
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2012.07.036es_ES
dc.identifier.urihttp://hdl.handle.net/10261/73437es_ES
dc.language.isoenges_ES
dc.publisherElsevier Science BV, PO Box 211, 1000 AE Amsterdam, Netherlandses_ES
dc.relation235 (2) 189-194 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAnxiolytic effects of ethanol are partially related to a reduced expression of adenylyl cyclase 5 but not to mu-opioid receptor activation in rat nucleus accumbenses_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria Ramon de la Fuente, Direcc Neurociencias, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailgortari@imp.edu.mxes_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural brain researches_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1872-7549es_ES
dc.identifier.doi10.1016/j.bbr.2012.07.036es_ES
dc.description.monthDices_ES
dc.description.abstractotrodiomaAnxiolytic effects of alcohol participate in the reinforcing properties of the drug, in which nucleus accumbens (NAcc) is implicated. The opioidergic system in NAcc is considered a main pathway involved in the emotional responses of animals: rats microinjected with morphine in NAcc and the systemic administration of mu-opioid receptors (MOR) agonists yield low anxiety scores in the elevated plus maze (EPM), a behavioral test of anxiety. However, the specific participation of NAcc MOR in the anxiolytic effect of ethanol has not been studied. AC5, a cAMP-synthezising adenylyl-cyclase, is highly expressed in NAcc| it is negatively coupled to MOR and has been implicated in anxiety levels of animals. We evaluated the anxiolytic effects of an intra-gastric administration of ethanol (2.5 g/kg) in animals subjected to EPM at 1, 4, and 8 h after drug or water exposure. Locomotion was assayed with the open-field test| we also measured accumbal AC5 and MOR mRNA levels by RT-PCR. After 1 h, ethanol-exposed animals showed anxiolytic-like behavior, as well as decreased and increased AC5 and MOR expression in NAcc, respectively. Intra-accumbal injection of beta-funaltrexamine (FNA), a MOR antagonist, did not block ethanol-induced anxiolysis, rather it induced a tendency to increase anxiety levels in the water-exposed group. FNA partially decreased accumbal AC5 expression in ethanol-treated rats. We concluded that AC5 in NAcc is participating in the emotional effects of ethanol| that MOR was not mediating the drug-induced AC5 reduction in NAcc nor the ethanol-induced anxiolysis. MOR only might be involved in basal levels of anxiety of animals. (C) 2012 Elsevier B.V. All rights reserved.es_ES
dc.subject.kwcAMPes_ES
dc.subject.kwNúcleo accumbenses_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwReceptores opioideses_ES
dc.subject.kwAdenilato ciclasaes_ES
dc.subject.kocAMPes_ES
dc.subject.koNucleus accumbenses_ES
dc.subject.koAnxietyes_ES
dc.subject.koOpioid receptorses_ES
dc.subject.koAdenylyl cyclasees_ES


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