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A chronic animal model of migraine, induced by repeated meningeal nociception, characterized by a behavioral and pharmacological approach

dc.creatorMelo-Carrillo, Agustín
dc.creatorLópez-Ávila, Alberto
dc.date.accessioned2017-06-30T03:50:31Z
dc.date.available2017-06-30T03:50:31Z
dc.date.issued2013es_ES
dc.identifier2316es_ES
dc.identifier.issn0333-1024es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6961
dc.identifier.urihttps://doi.org/10.1177/0333102413486320es_ES
dc.language.isoenges_ES
dc.publisherSAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDes_ES
dc.relation33 (13) 1096-1105 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleA chronic animal model of migraine, induced by repeated meningeal nociception, characterized by a behavioral and pharmacological approaches_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón Fuente Muñiz, Calzada México Xochimilco 101, Col. San Lorenzo Huipulco 14370, Tlalpan, México.es_ES
dc.contributor.emailneuropercepcion@gmail.comes_ES
dc.relation.jnabreviadoCEPHALALGIAes_ES
dc.relation.journalCephalalgia : an international journal of headachees_ES
dc.identifier.placeLondreses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1468-2982es_ES
dc.identifier.doi10.1177/0333102413486320es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaBackground Migraine is a chronic neurovascular disease characterized by recurrent unilateral headache, which induces incapacity. Despite all the progress that migraine research has provided, the neural mechanisms underlying the onset and maintenance of migraine attacks are poorly understood. Due to the complex characteristics of the disorder, it is difficult to develop a proper animal model that mimics all the clinical manifestations in humans. Objective Taking into account the principal characteristics of the disease, the aim of this study is to develop a chronic animal model of migraine in which we can reproduce behavioral and pharmacological phenomena similar to those displayed by migraineurs. Results Our animal model displayed behavioral and pharmacological results similar to those experienced by migraineurs. Specifically, there was a decrease in routine physical activity and an increase in resting behavior. Also, the animals exhibited a novel behavior that we called ipsilateral facial grooming behavior provoked by the meningeal nociception. Moreover, one of the drugs used as treatment for migraine reduced the manifestations previously described. Our results determine that the model mimics many of the clinical features that patients exhibit during migraine attacks. This model can contribute to further understanding of the pathophysiology and the study of novel therapeutic approaches.es_ES
dc.subject.kwMigrañaes_ES
dc.subject.kwDolor de cabezaes_ES
dc.subject.kwModeloes_ES
dc.subject.kwRataes_ES
dc.subject.kwTratamientoes_ES
dc.subject.kwTriptanoses_ES
dc.subject.koMigrainees_ES
dc.subject.koHeadachees_ES
dc.subject.koModeles_ES
dc.subject.koRates_ES
dc.subject.koTreatmentes_ES
dc.subject.koTriptanses_ES


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