Mostrar el registro sencillo del ítem

Antidepressant-Like Effect of Different Estrogenic Compounds in the Forced Swimming Test

dc.creatorEstrada-Camarena, Erika
dc.creatorFernández-Guasti, Alonso
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-30T03:47:10Z
dc.date.available2017-06-30T03:47:10Z
dc.date.issued2003es_ES
dc.identifier2258es_ES
dc.identifier.issn0893-133Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6905
dc.identifier.urihttps://doi.org/10.1038/sj.npp.1300097es_ES
dc.language.isoenges_ES
dc.publisherAmerican College of Neuropsychopharmacologyes_ES
dc.relation28 (5) 830-838 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntidepressant-Like Effect of Different Estrogenic Compounds in the Forced Swimming Testes_ES
dc.typearticlees_ES
dc.contributor.affiliationDepto de Farmacobiología CINVESTAV-IPN, México DF, Méxicoes_ES
dc.contributor.emailestrada@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROPSYCHOPHARMACOLOGYes_ES
dc.relation.journalNeuropsychopharmacologyes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1740-634Xes_ES
dc.identifier.doidoi:10.1038/sj.npp.1300097es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe present study evaluated the possible antidepressant-like action of the natural estrogen 17b-estradiol (E2, 2.5–10 mg/rat), the synthetic steroidal estrogen ethinyl-estradiol (EE2, 1.25–10.0 mg/rat), and the nonsteroidal synthetic estrogen, diethyl-stilbestrol (DES, 0.25–1.0 mg/rat) in ovariectomized adult female Wistar rats using the forced swimming test (FST). The behavioral profile induced by the estrogens was compared with that induced by the antidepressants fluoxetine (FLX, 2.5–10 mg/kg) and desipramine (DMI, 2.5–10 mg/kg). In addition, the temporal course of the antidepressant-like action of the estrogenic compounds was analyzed. FLX and DMI induced an antidepressant-like effect characterized by a reduced immobility and increased swimming for FLX and decreased immobility and increased climbing for DMI. Both E2 and EE2 produced a decrease in immobility and an increase in swimming, suggesting an antidepressant-like action. DES did not affect the responses in this animal model of depression at any dose tested. The time course analysis of the actions of E2 (10 mg/rat) and EE2 (5 mg/rat) showed that both compounds induced an antidepressant-like effect observed 1 h after their injection lasting for 2–3 days.es_ES
dc.subject.kw17b-estradioles_ES
dc.subject.kwEtinil-estradioles_ES
dc.subject.kwDietilestilbestroles_ES
dc.subject.kwAntidepresivoses_ES
dc.subject.kwPrueba de natación forzadaes_ES
dc.subject.kwFluoxetinaes_ES
dc.subject.kwDesipraminaes_ES
dc.subject.ko17b-estradioles_ES
dc.subject.koEthinyl-estradioles_ES
dc.subject.koDiethylstilbestroles_ES
dc.subject.koAntidepressantses_ES
dc.subject.koForced swimming testes_ES
dc.subject.koFluoxetinees_ES
dc.subject.koDesipraminees_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem