Mostrar el registro sencillo del ítem

Participation of the 5-HT1A Receptor in the Antidepressant-Like Effect of Estrogens in the Forced Swimming Test

dc.creatorEstrada-Camarena, Erika
dc.creatorFernández-Guasti, Alonso
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-30T03:47:06Z
dc.date.available2017-06-30T03:47:06Z
dc.date.issued2006es_ES
dc.identifier2257es_ES
dc.identifier.issn0893-133Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6904
dc.identifier.urihttps://doi.org/10.1038/sj.npp.1300821es_ES
dc.language.isoenges_ES
dc.publisherAmerican College of Neuropsychopharmacologyes_ES
dc.relation31 (2) 247-255 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleParticipation of the 5-HT1A Receptor in the Antidepressant-Like Effect of Estrogens in the Forced Swimming Testes_ES
dc.typearticlees_ES
dc.contributor.affiliationSubdirección de Neurociencias, Instituto Nacional de Psiquiatría 'Ramón de la Fuente Muñíz', México City, DF, Méxicoes_ES
dc.contributor.emailclopezr@mail.cinvestav.mxes_ES
dc.relation.jnabreviadoNEUROPSYCHOPHARMACOLOGYes_ES
dc.relation.journalNeuropsychopharmacologyes_ES
dc.identifier.placeNew Yorkes_ES
dc.date.published2006es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.eissn1740-634Xes_ES
dc.identifier.doidoi:10.1038/sj.npp.1300821es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaThe aim of the present study was to explore the possible participation of the 5-HT1A receptor in the antidepressant-like action of two estrogenic compounds: 17b-estradiol (E2) and ethynil-estradiol (EE2) in the FST. Ovariectomized female Wistar rats were used in all experiments. As a positive control, the effect of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n)-propil-aminotetraline (8-OH-DPAT; 0.0625, 0.125, 0.25 and 0.5 mg/kg) alone or in combination with WAY 100635 (0.5 and 1.0 mg/kg) was analyzed in the FST. In order to analyze the participation of the 5-HT1A receptor in the antidepressant-like actions of estrogens, the effect of the selective antagonist WAY 100635 (0.5 and 1.0 mg/kg) in combination with E2 (10 mg/rat) and EE2 (5 mg/rat) was studied in the FST. In this case, WAY 100635 was administered either simultaneously with the estrogens (48 h before the FST test) or 30 min before the FST. On the other hand, a suboptimal dose of 8-OH-DPAT (0.0625 mg/kg), combined with a noneffective dose of E2 (2.5 mg/rat) or EE2 (1.25 mg/rat), was tested in the FST. The results showed that 8-OH-DPAT (0.25 and 0.5 mg/kg), E2 (10 mg/rat), and EE2 (5 mg/rat), by themselves, exerted an antidepressant-like action. The antagonist to the 5-HT1A receptor WAY 100635, when applied together with 8-OH-DPAT or E2, blocked their antidepressant-like actions, but not the one induced by EE2. Interestingly, when the antagonist was applied 30 min before the FST, it was able to cancel the actions of EE2 on immobility behavior, and had no effect on the actions of E2. Finally, when a subthreshold dose of 8-OH-DPAT was combined with a noneffective dose of either E2 or EE2, an antidepressant-like action was observed. The results support the notion that the 5-HT1A receptor is one of the mediators of the antidepressant-like action of E2, and could indirectly contribute to the one induced by EE2.es_ES
dc.subject.kw17b-estradioles_ES
dc.subject.kwEtinil-estradioles_ES
dc.subject.kwReceptor de 5-HT1Aes_ES
dc.subject.kwCAMINO 100635es_ES
dc.subject.kw8-OH-DPATes_ES
dc.subject.kwPrueba de natación forzadaes_ES
dc.subject.ko17b-estradioles_ES
dc.subject.koEthinyl-estradioles_ES
dc.subject.ko5-HT1A receptores_ES
dc.subject.koWAY 100635es_ES
dc.subject.ko8-OH-DPATes_ES
dc.subject.koForced swimming testes_ES


Ficheros en el ítem

FicherosTamañoFormatoVer

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem