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Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy

dc.creatorSánchez, María Gabriela
dc.creatorEstrada-Camarena, Erika
dc.creatorBélanger, Nancy
dc.creatorMorissette, Marc
dc.creatorDi Paolo, Thérèse
dc.date.accessioned2017-06-30T03:47:02Z
dc.date.available2017-06-30T03:47:02Z
dc.date.issued2011es_ES
dc.identifier2256es_ES
dc.identifier.issn0028-3908es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6903
dc.identifier.urihttps://doi.org/10.1016/j.neuropharm.2010.11.024es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation60 (4) 642-652 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleEstradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomyes_ES
dc.typearticlees_ES
dc.contributor.affiliationMolecular Endocrinology and Genomic Research Center, Centre de recherche du CHUQ (CHUL), 2705 Laurier Boulevard, Quebec (QC), Canada G1V 4G2es_ES
dc.contributor.emailtherese.dipaolo@crchul.ulaval.ca (T. Di Paolo)es_ES
dc.relation.jnabreviadoNEUROPHARMACOLOGYes_ES
dc.relation.journalNeuropharmacologyes_ES
dc.identifier.placeOxfordes_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doidoi:10.1016/j.neuropharm.2010.11.024es_ES
dc.description.monthMares_ES
dc.description.abstractotrodiomaDepression is common in Parkinson’s disease and an imbalance in serotonin neurotransmission could be implicated. Estradiol is reported to modulate brain serotonin systems of rodents and monkeys, but this has not been explored in primate models of Parkinson’s disease. Thus, the present study investigated the effect of estradiol on 5-HT1A and 5-HT2A serotonin receptors in the cortex, striatum and raphe nucleus of long-term ovariectomized hemiparkinsonian monkeys. Seven monkeys were ovariectomized and received a month later a unilateral lesion with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Four years after lesion and ovariectomy, three received a month of treatment with 17b-estradiol and four the vehicle. Autoradiography of [3H]8-OH-DPAT specific binding to 5-HT1A receptors showed a decrease in the frontal cortex of monkeys treated with 17b-estradiol in both hemispheres of the brain. [3H] ketanserin specific binding to 5-HT2A receptors was increased in the frontal cortex and the striatum of monkeys treated with 17b-estradiol in both the lesioned and intact sides of the brain. Autoradiography of [35S]GTPgS specific binding stimulated with R-(_)-8-OH-DPAT showed a decrease in the percentage of stimulation in the frontal cortex of monkeys treated with 17b-estradiol in both hemispheres of the brain and in the dorsal raphe nucleus. Treatment with 17b-estradiol was initiated a long time after ovariectomy in monkeys to model post menopausal hormonal conditions and showed that serotonin receptors were still responsive in the brain regions investigated. These results support a role for 17b-estradiol on serotonin activity in Parkinson’s disease and could be useful for treatment of depression associated with this disease.es_ES
dc.subject.kwEnfermedad de parkinsones_ES
dc.subject.kwDepresiónes_ES
dc.subject.kwEstrógenoes_ES
dc.subject.kwMono MPTPes_ES
dc.subject.kwReceptores de 5-HTes_ES
dc.subject.koParkinson diseasees_ES
dc.subject.koDepressiones_ES
dc.subject.koEstrogenes_ES
dc.subject.koMPTP monkeyes_ES
dc.subject.ko5-HT receptorses_ES


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