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Participation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mecanism of action

dc.creatorPaéz-Martínez, Nayeli
dc.creatorAldrete-Audiffred, Jorge
dc.creatorGallardo-Tenorio, Alfredo
dc.creatorCastro-García, Mario
dc.creatorEstrada-Camarena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.date.accessioned2017-06-30T03:46:47Z
dc.date.available2017-06-30T03:46:47Z
dc.date.issued2013es_ES
dc.identifier2251es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6898
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2012.10.004es_ES
dc.language.isoenges_ES
dc.publisherElsevier B.V.es_ES
dc.relation698 (1-3) 178-185 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleParticipation of GABAA, GABAB receptors and neurosteroids in toluene-induced hypothermia: Evidence of concentration-dependent differences in the mecanism of actiones_ES
dc.typearticlees_ES
dc.contributor.affiliationSección de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Col. Santo Tomás, C.P.11340, Mexico City, Mexico.es_ES
dc.contributor.emailnayepam@yahoo.com.mxes_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.doihttp://dx.doi.org/10.1016/j.ejphar.2012.10.004es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaToluene is a misused substance that modifies y-aminobutyric acid (GABA) release and shares behavioral and molecular effects with GABAA and GABAB receptor agonists. GABAergic compounds are involved in thermoregulation processes and volatile substance users have reported that one of the reasons to inhale is to avoid feeling cold. At present, no studies have analyzed the effects of inhalants on body temperature and the mechanism of action involved. Thus, the main purpose of this study was to evaluate the effects of a (60min) acute toluene inhalation (2000,4000 and 6000 ppm) in core temperature. In addition, we tried to prevent the changes of temperature induced by toluene with the specific GABAA receptor blockers picrotoxin (0.01–0.1mg/kg), bicuculline (0.1–0.3mg/kg), and flumazenil (3–30mg/kg); the GABAB receptor antagonist phaclofen (10–30mg/kg) and the neuroster- oid synthesis inhibitor finasteride (10–30mg/kg). Results show that toluene reduced core temperature in mice in a concentration-dependent manner. The hypothermia produced by 4000 ppm toluene was prevented by picrotox in, bicuculline, phaclofen and finasteride but not by flumazenil. Incontrastnone of these antagonists tested blocked the effects of 6000 ppm toluene. In conclusion, toluene decreases core temperature, GABA receptors and neurosteroids participate intoluene’s action at 4000 ppm; but other mechanisms of action are involved in the hypothermic effects of 6000 ppm toluene.es_ES
dc.subject.kwToluenoes_ES
dc.subject.kwHiportemiaes_ES
dc.subject.kwReceptores GABAAes_ES
dc.subject.kwReceptores GABABes_ES
dc.subject.kwNeuroesteroideses_ES
dc.subject.koToluenees_ES
dc.subject.koHypothermiaes_ES
dc.subject.koGABAA receptorses_ES
dc.subject.koGABAB receptorses_ES
dc.subject.koNeurosteroidses_ES


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