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dc.creatorWolf, Susanne A
dc.creatorBick-Sander, Anika
dc.creatorFabel, Klaus
dc.creatorLeal-Galicia, Perla
dc.creatorTauber, Svantje
dc.creatorRamírez-Rodríguez, Gerardo
dc.creatorMüller, Anke
dc.creatorMelnik, Andre
dc.creatorWaltinger, Tim P
dc.creatorUllrich, Oliver
dc.creatorKempermann, Gerd
dc.date.accessioned2017-06-30T03:44:56Z
dc.date.available2017-06-30T03:44:56Z
dc.date.issued2010es_ES
dc.identifier2214es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6860
dc.identifier.urihttps://doi.org/10.1186/1478-811X-8-12es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898685/es_ES
dc.description.abstractBackground: Adult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid system. Whereas the impact of synthetic cannabinoids on the neuronal progenitor cells has been described, there has been lack of information about the action of plant-derived extracts on neurogenesis. Therefore we here focused on the effects of _9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) fed to female C57Bl/6 and Nestin-GFP-reporter mice on proliferation and maturation of neuronal progenitor cells and spatial learning performance. In addition we used cannabinoid receptor 1 (CB1) deficient mice and treatment with CB1 antagonist AM251 in Nestin-GFP-reporter mice to investigate the role of the CB1 receptor in adult neurogenesis in detail. Results: THC and CBD differed in their effects on spatial learning and adult neurogenesis. CBD did not impair learning but increased adult neurogenesis, whereas THC reduced learning without affecting adult neurogenesis. We found the neurogenic effect of CBD to be dependent on the CB1 receptor, which is expressed over the whole dentate gyrus. Similarly, the neurogenic effect of environmental enrichment and voluntary wheel running depends on the presence of the CB1 receptor. We found that in the absence of CB1 receptors, cell proliferation was increased and neuronal differentiation reduced, which could be related to CB1 receptor mediated signaling in Doublecortin (DCX)-expressing intermediate progenitor cells. Conclusion: CB1 affected the stages of adult neurogenesis that involve intermediate highly proliferative progenitor cells and the survival and maturation of new neurons. The pro-neurogenic effects of CBD might explain some of the positive therapeutic features of CBD-based compounds.es_ES
dc.language.isoenges_ES
dc.relation8 (12) 1-14 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesises_ES
dc.typearticlees_ES
dc.contributor.affiliationMax Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Berlin, Germanyes_ES
dc.contributor.emailgerd.kempermann@crt-dresden.dees_ES
dc.relation.jnabreviadoCELL COMMUN SIGNALes_ES
dc.relation.journalCell communication and signalinges_ES
dc.identifier.placeLondreses_ES
dc.date.published2010es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1478-811Xes_ES
dc.identifier.doi10.1186/1478-811X-8-12es_ES


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