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Acute stress further decreases the effect of ovariectomy on immobility behavior and hippocampal cell survival in rats

dc.creatorVega-Rivera, Nelly M.
dc.creatorFernández-Guasti, Alonso
dc.creatorRamírez-Rodríguez, Gerardo
dc.creatorEstrada-Camarena, Erika
dc.date.accessioned2017-06-30T03:44:53Z
dc.date.available2017-06-30T03:44:53Z
dc.date.issued2013es_ES
dc.identifier2213es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6859
dc.identifier.urihttps://doi.org/10.1016/j.psyneuen.2012.12.008es_ES
dc.language.isoenges_ES
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDes_ES
dc.relation38 () 1407-1417 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAcute stress further decreases the effect of ovariectomy on immobility behavior and hippocampal cell survival in ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratory of Neuropsychopharmacology, Division of Neurosciences, National Institute of Psychiatry, Me´xico, D.F., Mexicoes_ES
dc.contributor.emailestrada@imp.edu.mxes_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.identifier.placeOxfordes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.doi10.1016/j.psyneuen.2012.12.008es_ES
dc.description.monthEnees_ES
dc.description.abstractotrodiomaMost studies relating experimental depression and neurogenesis use mainly male rodents subjected to models of chronic stress. The forced swimming test (FST) is a widely utilized model of acute stress, but its effects on the neurogenic process in the hippocampus using females in different endocrine conditions has not been explored. The aim of this study was to evaluate the cell proliferation and early-, short- and long-lasting effects of forced swimming (FS) on adult hippocampal neurogenesis in rats in two endocrine conditions: proestrous and ovariectomized. To determine cell proliferation we used the endogenous marker Ki67. Cell survival was established with the thymidine analog, BrdU (75 mg/kg, 2/12, i.p.), which was administered before FS to proestrous and ovariectomized rats. FS increased immobility and corticosterone levels in OVX but not in rats in proestrus. In addition, FS did not affect cell proliferation but significantly decreased the number of BrdU-labeled cells at 2 h only in OVX-rats, an effect that remained for 3 and 14 days after FS. Data are discussed taking into consideration the relationship between gonadal and adrenal hormones in adult hippocampal neurogenesis in adult females. Our data also support the use of FS as a model for studying neurogenesis.es_ES
dc.subject.kwEstrés agudoes_ES
dc.subject.kwPrueba de natación forzadaes_ES
dc.subject.kwProliferación celulares_ES
dc.subject.kwSupervivencia celulares_ES
dc.subject.kwNeurogénesises_ES
dc.subject.koAcute stresses_ES
dc.subject.koForced swimming testes_ES
dc.subject.koCell proliferationes_ES
dc.subject.koCell survivales_ES
dc.subject.koNeurogenesises_ES


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