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Electroencephalographic activity in neonatal ventral hippocampus lesion in adult rats

dc.creatorValdés-Cruz, Alejandro
dc.creatorNegrete-Díaz, José
dc.creatorMagdaleno-Madrigal, Víctor
dc.creatorMartínez-Vargas, David
dc.creatorFernández-Mas, Rodrigo
dc.creatorAlmazán-Alvarado, Salvador
dc.creatorTorres-García, Evelina María
dc.creatorFlores, Gonzalo
dc.date.accessioned2017-06-30T03:44:51Z
dc.date.available2017-06-30T03:44:51Z
dc.date.issued2012es_ES
dc.identifier2212es_ES
dc.identifier.issn0887-4476es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6858
dc.identifier.urihttps://doi.org/10.1002/syn.21563es_ES
dc.language.isoenges_ES
dc.publisherWILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USAes_ES
dc.relation66 (8) 738-746 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshComparative behavioral-Changeses_ES
dc.titleElectroencephalographic activity in neonatal ventral hippocampus lesion in adult ratses_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquiatria Ramon Fuente Muniz, Direcc Invest Neurociencias, Calz Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.es_ES
dc.contributor.emailalevalc@imp.edu.mxes_ES
dc.relation.jnabreviadoSYNAPSEes_ES
dc.relation.journalSynapsees_ES
dc.identifier.placeNew Jerseyes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1098-2396es_ES
dc.identifier.doi10.1002/syn.21563   es_ES
dc.description.monthAgoes_ES
dc.description.abstractotrodiomaA neonatal ventral hippocampal lesion (NVHL) in rats has been commonly used as a neurodevelopmental model to mimic schizophrenia-like behaviors. Recently, we reported that NVHL resulted in dendritic retraction and spine loss in pyramidal neurons of the prefrontal cortex (PFC). In addition, the hippocampus and PFC are important structures in the regulation of the electroencephalographic (EEG) activity. Patients with PFC lesions show deficits in the EEG activity. This study aimed to determine whether the EEG activity was altered in NVHL rats. In addition, we also analyzed the locomotor activity induced by a novel environment and exploratory behavior using the hole-board test. Consistent with the behavioral findings, the EEG analysis of the cortical regions showed that the NVHL rats displayed a lower power in cortical bands. At 1-8 Hz, 9-14 Hz, and 15-30 Hz bands, our findings showed a decrease in the absolute power of the parietal and occipital cortices recordings. In addition, the NVHL rats also showed a reduction in the exploratory behavior tested using the hole-board test. In conclusion, this study demonstrated that the EEG activity was reduced in adult NVHL rats and suggests that this may play a role in the behavioral changes observed in this neurodevelopmental model of schizophrenia. Synapse, 2012. (c) 2012 Wiley Periodicals, Inc.es_ES
dc.subject.meshmAnimals, Newbornes_ES
dc.subject.meshmDisease Models, Animales_ES
dc.subject.meshmElectroencephalographyes_ES
dc.subject.meshmExploratory Behaviores_ES
dc.subject.meshmHippocampus-Growth & developmentes_ES
dc.subject.meshmHippocampus-Pathologyes_ES
dc.subject.meshmHippocampus-Physiopathologyes_ES
dc.subject.meshmMotor Activityes_ES
dc.subject.meshmRatses_ES
dc.subject.meshmRats, Sprague-Dawleyes_ES
dc.subject.meshmSchizophrenia-Pathologyes_ES
dc.subject.meshmSchizophrenia-Physiopathologyes_ES
dc.subject.meshmAnimalses_ES
dc.subject.kwCortezas cerebraleses_ES
dc.subject.kwElectroencefalografía-Actividades_ES
dc.subject.kwVentral neonatales_ES
dc.subject.kwEsquizofreniaes_ES
dc.subject.koCerebral corticeses_ES
dc.subject.koElectroencephalography-Activityes_ES
dc.subject.koNeonatal ventrales_ES
dc.subject.koHippocampus lesiones_ES
dc.subject.koSchizophreniaes_ES


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