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No association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican population

dc.creatorTovilla-Zarate, Carlos
dc.creatorCamarena Medellín, Beatriz
dc.creatorFresán, Ana
dc.creatorLópez-Narváez, Lilia
dc.creatorGonzález Castro, Thelma Beatriz
dc.creatorJuárez Rojo, Isela
dc.creatorRamírez-Bello, Julian
dc.creatorGenis, Alma
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-30T03:44:38Z
dc.date.available2017-06-30T03:44:38Z
dc.date.issued2013es_ES
dc.identifier2208es_ES
dc.identifier.issn0301-4851es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6854
dc.identifier.urihttps://doi.org/10.1007/s11033-012-2264-xes_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538011/es_ES
dc.language.isoenges_ES
dc.publisherSPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSes_ES
dc.relation40 (2) 2053-2058 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleNo association between catechol-o-methyltransferase Val108/158Met polymorphism and schizophrenia or its clinical symptomatology in a Mexican populationes_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Juarez Autonoma Tabasco, Div Acad Multidisciplinaria Comalcalco, Cuarta Secc, Comalcalco 86650, Tabasco, Mexico.es_ES
dc.contributor.emailalfonso_tovillaz@yahoo.com.mxes_ES
dc.relation.jnabreviadoMOL BIOL REPes_ES
dc.relation.journalMolecular biology reportses_ES
dc.identifier.placeNetherlandses_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1573-4978es_ES
dc.identifier.doi10.1007/s11033-012-2264-x   es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaThe gene coding for catecol-o-methyltransferase (COMT), participant in the metabolism of catecholamines, has long been implicated as a candidate gene for schizophrenia. We determined the relation of the COMT Val108/158Met polymorphism with schizophrenia or its symptomatology (negative, disorganized and psychotic dimension). We conducted a case-control study comprising 186 patients with schizophrenia and 247 controls. The diagnosis of schizophrenia was established using the DSM-IV criteria for this illness. The clinical symptomatology was assessed through the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms. No significant differences were found in the distribution of alleles (chi 2 = 0.01, df = 1, p = 0.90) or genotypes (chi 2 = 1.66, df = 2, p = 0.43) between schizophrenic patients and the control group. Multivariate analysis showed that the COMT Val108/158Met polymorphism has no influence in the clinical symptomatology of schizophrenia. Our results showed no association between COMT Val108/158Met and schizophrenia or evidence for an association between COMT and the clinical symptomatology of this illness. This suggests that the COMT gene may not contribute to the risk for schizophrenia among the Mexican population.es_ES
dc.subject.kwEsquizofreniaes_ES
dc.subject.kwCOMTes_ES
dc.subject.kwAsociaciónes_ES
dc.subject.kwPoblación mexicanaes_ES
dc.subject.kwSintomatología clínicaes_ES
dc.subject.koSchizophreniaes_ES
dc.subject.koCOMTes_ES
dc.subject.koAssociationes_ES
dc.subject.koMexican populationes_ES
dc.subject.koClinical symptomatologyes_ES


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