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APOE-epsilon 3 and APOE-219G Haplotypes Increase the Risk for Schizophrenia in Sibling Pairs

dc.creatorTovilla-Zarate, Carlos
dc.creatorCamarena Medellín, Beatriz
dc.creatorFresán, Ana
dc.creatorApiquián, Rogelio
dc.creatorDassori, Albana
dc.creatorMedina, Rolando
dc.creatorEscamilla, Michael
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-30T03:44:36Z
dc.date.available2017-06-30T03:44:36Z
dc.date.issued2009es_ES
dc.identifier2207es_ES
dc.identifier.issn0895-0172es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6853
dc.identifier.urihttps://doi.org/10.1176/jnp.2009.21.4.440es_ES
dc.language.isoenges_ES
dc.publisherAMER PSYCHIATRIC PUBLISHING, INC, 1000 WILSON BOULEVARD, STE 1825, ARLINGTON, VA 22209-3901 USAes_ES
dc.relation21 (4) 440-444 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAPOE-epsilon 3 and APOE-219G Haplotypes Increase the Risk for Schizophrenia in Sibling Pairses_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Autonoma Ciudad Mexico, Escuela Ciencias Genom, Mexico City, DF, Mexicoes_ES
dc.contributor.emailnicolini_humberto@yahoo.comes_ES
dc.relation.jnabreviadoJ NEUROPSYCHIATRY CLIN NEUROSCIes_ES
dc.relation.journalThe Journal of neuropsychiatry and clinical neuroscienceses_ES
dc.identifier.placeArlingtones_ES
dc.date.published2009es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1545-7222es_ES
dc.description.abstractotrodiomaTo investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-epsilon 3 (chi(2)=6.24, p=0.01); this allele is mainly carried by female patients (chi(2)=8.33, p=0.003), whereas APOE-219G is preferentially transmitted in males (p=0.02). Furthermore, our results show that haplotypes APOE-epsilon 3/APOE-219G are associated with schizophrenia (chi(2)=11.61, p=0.01). These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican populationes_ES
dc.subject.koAPOLIPOPROTEIN-E GENOTYPEes_ES
dc.subject.koAPOE EPSILON-4 ALLELEes_ES
dc.subject.koREGULATORY REGIONes_ES
dc.subject.koDOWNS-SYNDROMEes_ES
dc.subject.koE GENEes_ES
dc.subject.koASSOCIATIONes_ES
dc.subject.koONSETes_ES
dc.subject.koPOLYMORPHISMSes_ES
dc.subject.koMETAANALYSISes_ES
dc.subject.koCHROMOSOMEes_ES


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