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CXCR5(+) T helper cells mediate protective immunity against tuberculosis

dc.creatorSlight, Samantha R.
dc.creatorRangel-Moreno, Javier
dc.creatorGopal, Radha
dc.creatorLin, Yinyao
dc.creatorJunecko, Beth A. Fallert
dc.creatorMehra, Smriti
dc.creatorSelman, Moises
dc.creatorBecerril-Villanueva, Enrique
dc.creatorBaquera-Heredia, Javier
dc.creatorPavón, Lenin
dc.creatorKaushal, Deepak
dc.creatorReinhart, Todd A.
dc.creatorRandall, Troy D.
dc.creatorKhaderl, Shabaana A.
dc.date.accessioned2017-06-30T03:44:33Z
dc.date.available2017-06-30T03:44:33Z
dc.date.issued2013es_ES
dc.identifier2206es_ES
dc.identifier.issn0021-9738es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6852
dc.identifier.urihttps://doi.org/10.1172/JCI65728es_ES
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561804/es_ES
dc.language.isoenges_ES
dc.publisherAMER SOC CLINICAL INVESTIGATION INC, 35 RESEARCH DR, STE 300, ANN ARBOR, MI 48103 USAes_ES
dc.relation123 (2) 712-726 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleCXCR5(+) T helper cells mediate protective immunity against tuberculosises_ES
dc.typearticlees_ES
dc.contributor.affiliationUniv Pittsburgh, Sch Med, Div Infect Dis, Childrens Hosp Pittsburgh UPMC,Rangos Res Ctr 912, 4401 Penn Ave, Pittsburgh, PA 15224 USA.es_ES
dc.contributor.emailShabaana.Khader@chp.edues_ES
dc.relation.jnabreviadoJ CLIN INVESTes_ES
dc.relation.journalThe Journal of clinical investigationes_ES
dc.identifier.placeAnn Arbor, MIes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1558-8238es_ES
dc.identifier.doi10.1172/JCI65728   es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaOne third of the world's population is infected with Mycobacterium tuberculosis (Mtb). Although most infected people remain asymptomatic, they have a 10% lifetime risk of developing active tuberculosis (TB). Thus, the current challenge is to identify immune parameters that distinguish individuals with latent TB from those with active TB. Using human and experimental models of Mtb infection, we demonstrated that organized ectopic lymphoid structures containing CXCR5(+) T cells were present in Mtb-infected lungs. In addition, we found that in experimental Mtb infection models, the presence of CXCR5(+) T cells within ectopic lymphoid structures was associated with immune control. Furthermore, in a mouse model of Mtb infection, we showed that activated CD4(+)CXCR5(+) T cells accumulated in Mtb-infected lungs and produced proinflammatory cytokines. Mice deficient in Cxcr5 had increased susceptibility to TB due to defective T cell localization within the lung parenchyma. We demonstrated that CXCR5 expression in T cells mediated correct T cell localization within TB granulomas, promoted efficient macrophage activation, protected against Mtb infection, and facilitated lymphoid follicle formation. These data demonstrate that CD4(+)CXCR5(+) T cells play a protective role in the immune response against TB and highlight their potential use for future TB vaccine design and therapy.es_ES
dc.subject.koSIMIAN IMMUNODEFICIENCY VIRUSes_ES
dc.subject.koFOLLICULAR DENDRITIC CELLSes_ES
dc.subject.koLYMPHOID-TISSUE IBALTes_ES
dc.subject.koMYCOBACTERIUM-TUBERCULOSISes_ES
dc.subject.koCHEMOKINE RECEPTORes_ES
dc.subject.koATTRACTING CHEMOKINE-1es_ES
dc.subject.koRHEUMATOID-ARTHRITISes_ES
dc.subject.koGERMINAL CENTERes_ES
dc.subject.koLOCAL IMMUNITYes_ES
dc.subject.koHOST-DEFENSEes_ES


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