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dc.creatorSimón-Arceo, Karina
dc.creatorRamírez-Salado, Ignacio
dc.creatorCalvo, José M.
dc.date.accessioned2017-06-30T03:44:29Z
dc.date.available2017-06-30T03:44:29Z
dc.date.issued2003es_ES
dc.identifier2205es_ES
dc.identifier.issn0161-8105es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6851
dc.identifier.urihttps://doi.org/10.1093/sleep/26.3.259es_ES
dc.description.abstractStudy Objectives: The effect of a vasoactive intestinal peptide (VIP) microinjection into the amygdaloid central (CN) and basal nuclei (BN) on sleep organization and on the number and pattern of occurrence of pontogeniculooccipital (PGO) waves was analyzed. Design: One group of 8 cats was studied in baseline conditions and after the microinjection of two doses of VIP applied into the CN and BN. Setting: Sleep research laboratory. Participants and Interventions: Eight cats were prepared with sleep-recording electrodes and with guide tubes in both amygdalae for saline and VIP microinjections. Neuropeptide doses of 0.10mug/1mul (30muM) and 0.33mug/1mu1 (99.24muM) were employed. Measurements and Results: Once the microinjection was applied, 23-hour polygraphic sleep recordings were performed for 5 consecutive days. Concomitantly the PGO waves were tape-recorded on each day and computationally analyzed. Results show that the 0.10mug/1mul microinjection produced no change. Unilateral VIP 0.33mug/1mul injection into the CN provoked a significant and lasting increase in the percentage of slow-wave sleep with PGO waves. Bilateral application of VIP increased the percentage of slow-wave sleep with PGO waves and rapid eye movement sleep for 5 days. Bilateral microinjection of the neuropeptide into the BN only enhanced the percentage of slow wave sleep with PGO waves. For both amygdaloid nuclei, we observed that VIP increased the number and modified the PGO wave pattern of occurrence during slow-wave sleep with PGO waves and during rapid eye movement sleep. Conclusions: The VIP microinjection into both the CN and BN induces increased amounts of rapid eye movement sleep, PGO waves, and slow-wave sleep with PGO waves, having a more robust effect on all of these three variables when applied into the CN.es_ES
dc.language.isoenges_ES
dc.publisherAMER ACAD SLEEP MEDICINE, 6301 BANDEL RD, STE 101, ROCHESTER, MN 55901 USAes_ES
dc.relation26 (3) 259-264 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleLong-lasting enhancement of rapid eye movement sleep and pontogeniculooccipital waves by vasoactive intestinal peptide microinjection into the amygdala temporal lobees_ES
dc.typearticlees_ES
dc.contributor.affiliationInst Nacl Psiquit Ramon de la Fuente, Div Invest Neurociencias, Dept Cronobiol, Caizada Mexico Xochimilco 101, Tlalpan 14370, Mexico.es_ES
dc.relation.jnabreviadoSLEEPes_ES
dc.relation.journalSleepes_ES
dc.identifier.placeRochesteres_ES
dc.date.published2003es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1550-9109es_ES
dc.description.monthMayes_ES
dc.subject.kwEnhancemen del sueño REMes_ES
dc.subject.kwOndas PGOes_ES
dc.subject.kwAmígdala del lóbulo temporales_ES
dc.subject.kwPéptido intestinal vasoactivoes_ES
dc.subject.kwGatoes_ES
dc.subject.koREM sleep enhancementes_ES
dc.subject.koPGO waveses_ES
dc.subject.koAmygdala temporal lobees_ES
dc.subject.koVasoactive intestinal peptidees_ES
dc.subject.koCates_ES


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