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Dopamine D4 receptor (DRD4) gene polymorphism in the first psychotic episode

dc.creatorRinetti, Gina
dc.creatorCamarena, Beatriz
dc.creatorCruz, Carlos
dc.creatorApiquián, Rogelio
dc.creatorFresán, Ana
dc.creatorPáez, Francisco
dc.creatorNicolini, Humberto
dc.date.accessioned2017-06-30T03:44:10Z
dc.date.available2017-06-30T03:44:10Z
dc.date.issued2001es_ES
dc.identifier2196es_ES
dc.identifier.issn0188-4409es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6843
dc.identifier.urihttps://doi.org/10.1016/S0188-4409(00)00257-5es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 655 AVENUE OF THE AMERICAS, NEW YORK, NY 10010 USAes_ES
dc.relation32 (1) 35-38 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.subject.meshD-2es_ES
dc.titleDopamine D4 receptor (DRD4) gene polymorphism in the first psychotic episodees_ES
dc.typearticlees_ES
dc.contributor.affiliationIMP, Div Invest Clinin, PUIS, Unidad Genet Mol Psiquiatr, Calzada Mexico Xochimilco 101,Col San Lorenzo Hui, Mexico City 14080, DF, Mexico.es_ES
dc.contributor.emailnicolini_humberto@yahoo.comes_ES
dc.relation.jnabreviadoARCH MED RESes_ES
dc.relation.journalArchives of medical researches_ES
dc.identifier.placeMexico, D.F. : Instituto Mexicano del Seguro Sociales_ES
dc.date.published2001es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-5487es_ES
dc.identifier.doi10.1016/S0188-4409(00)00257-5   es_ES
dc.description.monthEne-Febes_ES
dc.description.abstractotrodiomaBackground. Dopamine D4 receptor (DRD4) has shown some interesting properties at genetic and possibly functional levels. It has been suggested that some molecular variants een of the DRD4 gene (e.g,, four and seven alleles) could be implicated in the pathogenesis of psychotic disorders. Additionally, the VNTR polymorphism could be implicated in part of the response to treatment with neuroleptics. This study tested the possible association between the 48-bp tandem repeats in exon 3 of the DRD4 gene and patients experiencing their first psychotic episode. Methods. Patients with a first psychotic episode (FPE, n = 37) were diagnosed and compared with a matched control group (n = 37). The FPE group was subdivided into two categories: those with nonaffective and those with affective psychoses. The variable number of tandem repeats (VNTR) region of the DRD4 gene was amplified by PCR procedures. Chi-square statistics and appropriate corrections and adjustments were used for data analysis. Results. A significantly lower frequency of the four repeat (4-R) carriers in the FPE group was observed. This association was sustained mainly by the affective psychotic group (chi (2) = 9.99 df = 2, p = 0.0073). Conclusions. Although these results require testing with stringent methods, it is suggested that the DRD4-4R allele may confer some protection against psychosis, mainly of the affective subtype. (C) 2001 IMSS. Published by Elsevier Science Inc.es_ES
dc.subject.kwPrimer episodio psicóticoes_ES
dc.subject.kwGenes_ES
dc.subject.koGenees_ES
dc.subject.koDRD4 receptores_ES
dc.subject.koFirst psychotic episodees_ES


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