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Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice

dc.creatorRamírez-Rodríguez, Gerardo
dc.creatorVega-Rivera, Nelly M.
dc.creatorBenítez-King, Gloria
dc.creatorCastro-García, Mario
dc.creatorOrtíz-López, Leonardo
dc.date.accessioned2017-06-30T03:44:07Z
dc.date.available2017-06-30T03:44:07Z
dc.date.issued2012es_ES
dc.identifier2195es_ES
dc.identifier.issn0304-3940es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6842
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2012.09.045es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSes_ES
dc.relation530, 53-58 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleMelatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of micees_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry, México, D.F., Mexicoes_ES
dc.contributor.emailgbernabe@imp.edu.mxes_ES
dc.relation.jnabreviadoNEUROSCI LETTes_ES
dc.relation.journalNeuroscience letterses_ES
dc.identifier.placeAmsterdames_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7972es_ES
dc.identifier.doi10.1016/j.neulet.2012.09.045es_ES
dc.description.monthSepes_ES
dc.description.abstractotrodiomaMelatonin modulates adult hippocampal neurogenesis in adult mice. Also, plasma melatonin levels and new neuron formation decline during aging probably causing cognitive alterations. In this study, we analyzed the impact of exogenous supplementation with melatonin in three key events of hippocampal neurogenesis during normal aging of mice. The analysis was performed in rodents treated with melatonin during 3, 6, 9 or 12 months. We found an increase in cell proliferation in the dentate gyrus of the hippocampus after 3, 6 and 9 months of treatment (>90%). Additionally, exogenous melatonin promoted survival of new cells in the dentate gyrus (>50%). Moreover, melatonin increased the number of doublecortin-labeled cells after 6 and 9 months of treatment (>150%). In contrast, melatonin administered during 12 months did not induce changes in hippocampal neurogenesis. Our results indicate that melatonin also modulates the neurogenic process in the hippocampus during normal aging of mice. Together, the data support melatonin as one of the positive endogenous regulators of neurogenesis during aging.es_ES
dc.subject.kwNeurogenesises_ES
dc.subject.kwMelatoninaes_ES
dc.subject.kwHipocampuses_ES
dc.subject.kwEnvejecimientoes_ES
dc.subject.kwBrdUes_ES
dc.subject.koNeurogenesises_ES
dc.subject.koMelatonines_ES
dc.subject.koHippocampuses_ES
dc.subject.koAginges_ES
dc.subject.koBrdUes_ES


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