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Increase in nitric oxide levels and mitochondrial membrane potential in platelets of untreated patients with major depression

dc.creatorMoreno, Julia
dc.creatorGaspar, Enrique
dc.creatorLópez-Bello, Guadalupe
dc.creatorJuárez, Eliuth
dc.creatorAlcazar-Leyva, Susana
dc.creatorGonzález-Trujano, Eva
dc.creatorPavón, Lenin
dc.creatorAlvarado-Vásquez, Noé
dc.date.accessioned2017-06-30T03:43:39Z
dc.date.available2017-06-30T03:43:39Z
dc.date.issued2013es_ES
dc.identifier2183es_ES
dc.identifier.issn0165-1781es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6831
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2012.12.024es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDes_ES
dc.relation209 (3) 447-452 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleIncrease in nitric oxide levels and mitochondrial membrane potential in platelets of untreated patients with major depressiones_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.contributor.emailnnooee@gmail.comes_ES
dc.relation.jnabreviadoPSYCHIATRY RESes_ES
dc.relation.journalPsychiatry Researches_ES
dc.identifier.placeClare, Irelandes_ES
dc.date.published2013es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7123es_ES
dc.identifier.doi10.1016/j.psychres.2012.12.024es_ES
dc.description.monthoctes_ES
dc.description.abstractotrodiomaAlterations in platelet activity have been associated with the onset of major depressive disorder (MDD) and with ischemic cardiovascular events through mechanisms that remain unknown. The present study evaluated nitric oxide (NO) levels, mitochondrial membrane potential (PMMP), and P-selectin expression in platelets from 30 untreated MDD patients and 30 matched controls by flow cytometry. In addition, tryptophan and serotonin concentrations were measured in the whole blood by high performance liquid chromatography. Patients were assessed with the Mini International Neuropsychiatric Interview and the Hamilton Depression Rating Scale. The patients had not had antidepressant treatment or any other pharmacological interventions for at least 1 year. MDD patients significantly differed from controls in levels of major fluorescent platelets for NO, PMMP, and P-selectin compared with those observed in control subjects. Serotonin concentrations in MDD patients did not differ from those in controls These results demonstrate that untreated MDD patients show increased platelet activation, suggesting an alteration in the platelet function.es_ES
dc.subject.kwTrastorno depresivo mayores_ES
dc.subject.kwPotencial de membrana mitocondrial de plaquetases_ES
dc.subject.kwSíntesis de óxido nítricoes_ES
dc.subject.koMajor depressive disorderes_ES
dc.subject.koMitochondriaes_ES
dc.subject.koPlateletses_ES
dc.subject.koPlatelet mitochondrial membrane potentiales_ES
dc.subject.koNitric oxide synthesises_ES


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