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Testosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugs

dc.creatorMartínez-Mota, Lucía
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-30T03:43:32Z
dc.date.available2017-06-30T03:43:32Z
dc.date.issued2004es_ES
dc.identifier2179es_ES
dc.identifier.issn0091-3057es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6828
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2004.05.016es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAes_ES
dc.relation78, 711-718 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTestosterone-dependent antidepressant-like effect of noradrenergic but not of serotonergic drugses_ES
dc.typearticlees_ES
dc.contributor.affiliationSubdirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatr??a Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan 14370 D.F., Mexicoes_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.relation.jnabreviadoPHARMACOL BIOCHEM BEHAVes_ES
dc.relation.journalPharmacology, biochemistry, and behaviores_ES
dc.identifier.placeTarrytown, NYes_ES
dc.date.published2004es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1873-5177es_ES
dc.identifier.doi10.1016/j.pbb.2004.05.016es_ES
dc.description.monthMayes_ES
dc.description.abstractotrodiomaThe main objective of this study was to analyze the effect of testosterone on the actions of antidepressant drugs in the forced swimming test (FST), an animal model that predicts antidepressant effects. In addition, the effect of testosterone propionate (TP) supplementation was evaluated in the same animal model using orchidectomized male rats. Initially, different doses (2.5, 5.0, and 10.0 mg/kg sc, three injections before the test) of desipramine (DMI), fluoxetine (FLX), and clomipramine (CMI) were administered to intact male rats to detect the effective dose in the FST. All drugs (at 10 mg/kg) produced an antidepressant effect, reflected as a reduction of immobility behavior. Neither orchidectomy per se nor TP supplementation (0.5 and 1.0 mg/rat sc, for 10 days) modified the behaviors evaluated in the FST. Orchidectomy blocked the antidepressant effect of DMI, FLX, and CMI (10 mg/kg), while TP supplementation (0.5 mg/rat, for 10 days) restored the antidepressant action of DMI, but not that of CMI or FLX. These findings indicate that testosterone participates in the antidepressant actions of DMI, a noradrenaline reuptake inhibitor, while other gonadal hormones might be involved in the antidepressant effects of the serotonin reuptake inhibitors (SSRIs) like FLX and CMI.es_ES
dc.subject.koTestosterone propionatees_ES
dc.subject.koAntidepressant effectes_ES
dc.subject.koForced swimming testes_ES
dc.subject.koDesipraminees_ES
dc.subject.koSerotonin reuptake inhibitorses_ES
dc.subject.koFluoxetinees_ES
dc.subject.koOrchidectomyes_ES
dc.subject.koClomipraminees_ES


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