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Antidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in mice

dc.creatorMartínez Vázquez, M.
dc.creatorEstrada Reyes, R.
dc.creatorAraujo Escalona, A.
dc.creatorLedesma Velázquez, I.
dc.creatorMartínez Mota, L.
dc.creatorMoreno, J.
dc.creatorHeinze, G.
dc.date.accessioned2017-06-30T03:43:29Z
dc.date.available2017-06-30T03:43:29Z
dc.date.issued2011es_ES
dc.identifier2177es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6826
dc.identifier.urihttps://doi.org/10.1016/j.jep.2011.10.033es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER IRELAND LTD, ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDes_ES
dc.relation139, 164-170 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleAntidepressant-like effects of an alkaloid extract of the aerial parts of Annona cherimolia in micees_ES
dc.typearticlees_ES
dc.contributor.affiliationInstituto de Química, Universidad Nacional Autónoma de México, Coyoacán, México, D.F. 04510, Mexicoes_ES
dc.contributor.emailrestrada@imp.edu.mxes_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.identifier.placeClare, Irelandes_ES
dc.date.published2011es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.doi10.1016/j.jep.2011.10.033es_ES
dc.description.monthOctes_ES
dc.description.abstractotrodiomaEthnopharmacological relevance: Several species of Annona (Annonaceae) are used in traditional Mexican medicine by their anti-anxiety, anticonvulsant and tranquilizing properties. It has been reported that the alkaloids isolated from some species of the Annona have affinity to serotonergic 5-HT1A receptors and modulate dopaminergic transmission, which is involved in depressive disorders. Aim of the study: To investigate the antidepressant-like effect of an alkaloid extract from the aerial parts of Annona cherimola (TA) in mice. Materials and methods: The antidepressant-like effect was evaluated in the forced swimming test. To elucidate a possible mechanism of action, experiments of synergism with antidepressant drugs, such as imipramine (IMI), clomipramine (CLIMI), and fluoxetine (FLX), were carried out. The neurotransmitter content (DA: dopamine, 5HT: serotonin and its metabolites, HVA: homovanillic acid and 5HIAA: 5-hydroxyindoleacetic) in the whole brain of mice were also determined by HPLC method. TA chemical composition was determined using high performance liquid chromatography–electrospray mass spectrometry. Results: The results showed that repeated treatment with TA produced antidepressant-like effects in mice. This effect was not related to an increase in locomotor activity. Administration of TA facilitated the antidepressant effect of IMI and CLIMI as well as increased the turnover of DA and 5-HT. The alkaloids: 1,2-dimethoxy-5,6,6a,7-tetrahydro-4H-dibenzoquinoline-3,8,9,10-tetraol, anonaine, liriodenine, and nornuciferine were the main constituents of TA. Conclusions: Results showed that TA produces an antidepressant-like action from a generalized increase in monominergic turnover, supporting the use in tradicional medicine of Annona cherimolia, and strongly suggest its therapeutic potency as an antidepressant agent.es_ES
dc.subject.koAntidepressantes_ES
dc.subject.koAlkaloidses_ES
dc.subject.koAporphineses_ES
dc.subject.koForced swimming testes_ES


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