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Testosterone prevents but not reverses anhedonia in middle-aged males and lacks an effect on stress vulnerability in young adults

dc.creatorHerrera-Pérez, José Jaime
dc.creatorMartínez-Mota, Lucía
dc.creatorChavira, Roberto
dc.creatorFernández-Guasti, Alonso
dc.date.accessioned2017-06-30T03:43:06Z
dc.date.available2017-06-30T03:43:06Z
dc.date.issued2012es_ES
dc.identifier2167es_ES
dc.identifier.issn0018-506Xes_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/6816
dc.identifier.urihttps://doi.org/10.1016/j.yhbeh.2012.02.015es_ES
dc.language.isoenges_ES
dc.publisherELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAes_ES
dc.relation61, 623-630 p.es_ES
dc.relationversión del editores_ES
dc.rightsacceso cerradoes_ES
dc.titleTestosterone prevents but not reverses anhedonia in middle-aged males and lacks an effect on stress vulnerability in young adultses_ES
dc.typearticlees_ES
dc.contributor.affiliationLaboratorio de Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñíz”, México City, Mexicoes_ES
dc.contributor.emailjfernand@cinvestav.mxes_ES
dc.relation.jnabreviadoHORM BEHAVes_ES
dc.relation.journalHormones and Behaviores_ES
dc.identifier.placeNew York, NYes_ES
dc.date.published2012es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México.es_ES
dc.identifier.eissn1095-6867es_ES
dc.identifier.doi10.1016/j.yhbeh.2012.02.015es_ES
dc.description.monthFebes_ES
dc.description.abstractotrodiomaMiddle-aged male rats are more vulnerable than young adult ones to develop anhedonia when exposed to chronic mild stress (CMS). Clinical studies support the idea that in aged subjects the low testosterone (T) levels are related with their higher stress vulnerability and that this hormone possesses antidepressant-like actions. In this study we evaluated the role of gonadal hormones — mainly T — on the depressive-like behavior of middle-aged and young adult male rats submitted to CMS. In middle-aged rats we analyzed the effect of T restitution (at the levels of young adult animals) given 3 weeks before (experiment 1) or 3 weeks after (experiment 2) anhedonia development (indicated by a reduction in sucrose solution intake). T restitution before CMS effectively prevented anhedonia but failed to reverse it once installed. In young adult rats we studied if orchidectomy increased stress vulnerability and found that it failed to modify sucrose intake. These results indicate a stress-dependent differential effect of T in middle-aged rats an age differential role of gonadal hormones on the vulnerability to develop anhedonia. The results suggest that T is a resilience factor in middle-aged but not in young adult males.es_ES
dc.subject.koAginges_ES
dc.subject.koAnhedoniaes_ES
dc.subject.koChronic mild stresses_ES
dc.subject.koResiliencees_ES
dc.subject.koTestosteronees_ES
dc.subject.koAntidepressant-like effectes_ES


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